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uroporphyrinogen-III synthase activity

Known as: uroporphyrinogen-III cosynthetase activity, porphobilinogenase activity, uroporphyrinogen isomerase activity 
Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III. [EC:4.2.1.75, RHEA:18968]
National Institutes of Health

Papers overview

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2002
2002
Paraquat-generated Oxidative Stress in Rat Liver Induces Heme Oxygenase-1 and Aminolevulinic Acid Synthase
The in vivo effect of the known herbicide, paraquat, on both hepatic oxidative stress and heme metabolism was studied. A marked… Expand
2002
2002
Paraquat-generated oxidative stress in rat liver induces heme oxygenase-1 and aminolevulinic acid synthase.
The in vivo effect of the known herbicide, paraquat, on both hepatic oxidative stress and heme metabolism was studied. A marked… Expand
2000
2000
Effect of acetaminophen on heme metabolism in rat liver.
BACKGROUND AND AIMS Acetaminophen (APAP) or paracetamol is a hepatotoxic drug through mechanisms involving oxidative stress. To… Expand
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1987
1987
[Saccharomyces cerevisiae: porphobilinogenase activity in a wild-type strain and its heme-deficient mutant].
Properties of Porphobilinogenase (PBGase), the enzyme complex converting porphobilinogen (PBG) into uroporphyrinogens, were… Expand
1987
1987
[Saccharomyces cerevisiae: porphobilinogenase activity in a wild-type strain and its heme-deficient mutant].
Properties of Porphobilinogenase (PBGase), the enzyme complex converting porphobilinogen (PBG) into uroporphyrinogens, were… Expand
1981
1981
Porphyrin biosynthesis in Euglena gracilis--IV. an endogenous factor controlling the enzymic synthesis of porphyrinogens and its possible role in the treatment of some porphyrias.
Abstract 1. 1. Preliminary experiments with Euglena gracilis indicated that an endogenous factor which modified enzymic synthesis… Expand
1979
1979
Studies on porphyrin biosynthesis and enzymes involved in bovine congenital erythropoietic porphyria.
1. Porphyrin biosynthesis and the enzymes succinyl-CoA synthetase (EC 6.2.1.5), δ-aminolaevulinate synthase (EC 2.3.1.37… Expand
Highly Cited
1978
Highly Cited
1978
A simple method for measuring erythrocyte porphobilinogenase, and its use in the diagnosis of acute intermittent porphyria.
Abstract 1. l. A simple method for measuring erythrocyte porphobilinogenase activity has been devised. 2. 2. Red blood cells are… Expand
1971
1971
Studies on the porphobilinogen deaminase-uroporphyrinogen cosynthetase system of cultured soya-bean cells.
1. Porphobilinogenase was isolated and purified from soya-bean callus tissue; its components, porphobilinogen deaminase and… Expand
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1970
1970
Uroporphyrinogen III cosynthetase. Evidence for the existence of a polypyrrolic substrate in soybean callus tissue
The details of the reactions by which porphobilinogen (PBG) is converted into uroporphyrinogen III are still the subject of… Expand
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