ubiquitin-protein ligase activity

Known as: ubiquitin protein ligase activity, E3, ubiquitin protein-ligase activity 
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S --> X + S-ubiquitin, where X is either an E2 or E3… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
PINK1 kinase activates the E3 ubiquitin ligase Parkin to induce selective autophagy of damaged mitochondria. However, it has been… (More)
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Highly Cited
2004
Highly Cited
2004
Many hereditary and sporadic neurodegenerative disorders are characterized by the accumulation of aberrant proteins. In sporadic… (More)
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Highly Cited
2003
Highly Cited
2003
Rapid turnover of the tumor suppressor protein p53 requires the MDM2 ubiquitin ligase, and both interact with p300-CREB-binding… (More)
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Highly Cited
2003
Highly Cited
2003
Nucleotide excision repair (NER) is a major cellular defense against the carcinogenic effects of ultraviolet light from the sun… (More)
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Highly Cited
2001
Highly Cited
2001
BRCA1-BARD1 constitutes a heterodimeric RING finger complex associated through its N-terminal regions. Here we demonstrate that… (More)
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Highly Cited
2001
Highly Cited
2001
BRCA1 is a breast and ovarian cancer-specific tumor suppressor that seems to be involved in transcription and DNA repair. Here we… (More)
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Highly Cited
1999
Highly Cited
1999
We have demonstrated previously that the oncoprotein Mdm2 has a ubiquitin ligase activity for the tumor suppressor p53 protein… (More)
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Highly Cited
1999
Highly Cited
1999
We have identified two highly conserved RING finger proteins, ROC1 and ROC2, that are homologous to APC11, a subunit of the… (More)
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Highly Cited
1999
Highly Cited
1999
Ubiquitin-mediated proteolysis has a central role in controlling the intracellular levels of several important regulatory… (More)
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Highly Cited
1995
Highly Cited
1995
The ubiquitin-mediated degradation of mitotic cyclins is required for cells to exit from mitosis. Previous work with cell-free… (More)
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