ubiquitin-dependent protein catabolic process

Known as: ubiquitin-dependent proteolysis, ubiquitin-dependent protein catabolism, ubiquitin-dependent protein degradation 
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent… (More)
National Institutes of Health

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protein arginylation

Papers overview

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2012
2012
The Ubiquitin Ligase Nedd4-1 Participates in Denervation-Induced Skeletal Muscle Atrophy in Mice
Skeletal muscle atrophy is a consequence of muscle inactivity resulting from denervation, unloading and immobility. It… (More)
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Highly Cited
2007
Highly Cited
2007
The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.
Notch signaling is of crucial importance in normal T-cell development and Notch 1 is frequently mutated in T-cell acute… (More)
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2005
2005
Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation.
Ubiquitin plays essential roles in various cellular processes; therefore, it is of keen interest to study the structure-function… (More)
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Highly Cited
2004
Highly Cited
2004
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice.
Muscle wasting accompanies aging and pathological conditions ranging from cancer, cachexia, and diabetes to denervation and… (More)
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2003
2003
Enteral glutamine stimulates protein synthesis and decreases ubiquitin mRNA level in human gut mucosa.
Effects of glutamine on whole body and intestinal protein synthesis and on intestinal proteolysis were assessed in humans. Two… (More)
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Highly Cited
2000
Highly Cited
2000
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression.
The c-Myc oncoprotein plays an important role in the growth and proliferation of normal and neoplastic cells. To execute these… (More)
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Highly Cited
1998
Highly Cited
1998
mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway.
Upon activation in response to cellular stress or DNA damage, the p53 tumor suppressor induces the expression of gene products… (More)
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Highly Cited
1996
Highly Cited
1996
Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.
Recent studies suggest that sepsis-induced increase in muscle proteolysis mainly reflects energy-ubiquitin-dependent protein… (More)
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1995
1995
Inhibition of ubiquitin-mediated proteolysis by the Arabidopsis 26 S protease subunit S5a.
A variety of protease inhibitors have been used to study ubiquitin-dependent proteolysis by the 26 S protease. However, these… (More)
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Highly Cited
1994
Highly Cited
1994
Interferon-gamma induces different subunit organizations and functional diversity of proteasomes.
To obtain information on the role of proteasomes in the immune system, we examined the effect of a major immunomodulatory… (More)
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