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ubiquitin-dependent protein catabolic process
Known as:
ubiquitin-dependent proteolysis
, ubiquitin-dependent protein catabolism
, ubiquitin-dependent protein degradation
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The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent…
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National Institutes of Health
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Related topics
Related topics
1 relation
Narrower (1)
protein arginylation
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to…
A. Brockington
,
K. Ning
,
+7 authors
P. Shaw
Acta Neuropathologica
2012
Corpus ID: 8556895
A consistent clinical feature of amyotrophic lateral sclerosis (ALS) is the sparing of eye movements and the function of external…
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Highly Cited
2007
Highly Cited
2007
The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.
A. Malyukova
,
Takeaki Dohda
,
+7 authors
O. Sangfelt
Cancer Research
2007
Corpus ID: 17689140
Notch signaling is of crucial importance in normal T-cell development and Notch 1 is frequently mutated in T-cell acute…
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Highly Cited
2004
Highly Cited
2004
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice.
D. Cai
,
J. Frantz
,
+8 authors
S. Shoelson
Cell
2004
Corpus ID: 19076949
Muscle wasting accompanies aging and pathological conditions ranging from cancer, cachexia, and diabetes to denervation and…
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Review
2004
Review
2004
Aurora A, Meiosis and Mitosis
R. Crane
,
B. Gadea
,
L. Littlepage
,
Hua Wu
,
J. Ruderman
Biology of the Cell
2004
Corpus ID: 29416056
Highly Cited
2000
Highly Cited
2000
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression.
R. O'hagan
,
M. Ohh
,
+4 authors
R. DePinho
Genes & Development
2000
Corpus ID: 25715692
The c-Myc oncoprotein plays an important role in the growth and proliferation of normal and neoplastic cells. To execute these…
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Highly Cited
1998
Highly Cited
1998
mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway.
Y. C. Chang
,
Y. Lee
,
+5 authors
J. Magae
Cell growth & differentiation : the molecular…
1998
Corpus ID: 18243499
Upon activation in response to cellular stress or DNA damage, the p53 tumor suppressor induces the expression of gene products…
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Highly Cited
1996
Highly Cited
1996
In vivo ubiquitination and proteasome-mediated degradation of p53(1).
C. Maki
,
J. Huibregtse
,
P. Howley
Cancer Research
1996
Corpus ID: 22311159
The levels of the tumor suppressor protein p53 are generally quite low in normal cells, due in part to its rapid turnover…
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Highly Cited
1996
Highly Cited
1996
Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.
G. Tiao
,
J. Fagan
,
+4 authors
P. Hasselgren
Journal of Clinical Investigation
1996
Corpus ID: 62715
Recent studies suggest that sepsis-induced increase in muscle proteolysis mainly reflects energy-ubiquitin-dependent protein…
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Highly Cited
1995
Highly Cited
1995
Amyloid β-Protein Inhibits Ubiquitin-dependent Protein Degradation in Vitro(*)
L. Gregori
,
C. Fuchs
,
M. Figueiredo-Pereira
,
W. V. Van Nostrand
,
D. Goldgaber
Journal of Biological Chemistry
1995
Corpus ID: 12437747
Intraneuronal accumulation of ubiquitin conjugates in inclusion bodies and neurofibrillary tangles is a pathological feature of…
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Highly Cited
1994
Highly Cited
1994
Interferon-gamma induces different subunit organizations and functional diversity of proteasomes.
M. Aki
,
N. Shimbara
,
+7 authors
A. Ichihara
Journal of Biochemistry (Tokyo)
1994
Corpus ID: 23153912
To obtain information on the role of proteasomes in the immune system, we examined the effect of a major immunomodulatory…
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