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ubiquitin-dependent protein catabolic process

Known as: ubiquitin-dependent proteolysis, ubiquitin-dependent protein catabolism, ubiquitin-dependent protein degradation 
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent… Expand
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
A consistent clinical feature of amyotrophic lateral sclerosis (ALS) is the sparing of eye movements and the function of external… Expand
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Highly Cited
2007
Highly Cited
2007
Notch signaling is of crucial importance in normal T-cell development and Notch 1 is frequently mutated in T-cell acute… Expand
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Highly Cited
2004
Highly Cited
2004
Muscle wasting accompanies aging and pathological conditions ranging from cancer, cachexia, and diabetes to denervation and… Expand
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Highly Cited
2002
Highly Cited
2002
Rpn10, a subunit of the 26S proteasome, has been proposed to act as a receptor for multiubiquitin chains in ubiquitin-dependent… Expand
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Highly Cited
2000
Highly Cited
2000
The c-Myc oncoprotein plays an important role in the growth and proliferation of normal and neoplastic cells. To execute these… Expand
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Highly Cited
1998
Highly Cited
1998
Upon activation in response to cellular stress or DNA damage, the p53 tumor suppressor induces the expression of gene products… Expand
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Highly Cited
1996
Highly Cited
1996
The levels of the tumor suppressor protein p53 are generally quite low in normal cells, due in part to its rapid turnover… Expand
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Highly Cited
1996
Highly Cited
1996
Recent studies suggest that sepsis-induced increase in muscle proteolysis mainly reflects energy-ubiquitin-dependent protein… Expand
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Highly Cited
1995
Highly Cited
1995
Intraneuronal accumulation of ubiquitin conjugates in inclusion bodies and neurofibrillary tangles is a pathological feature of… Expand
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Highly Cited
1994
Highly Cited
1994
To obtain information on the role of proteasomes in the immune system, we examined the effect of a major immunomodulatory… Expand
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