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ubiquitin-dependent protein catabolic process

Known as: ubiquitin-dependent proteolysis, ubiquitin-dependent protein catabolism, ubiquitin-dependent protein degradation 
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent… 
National Institutes of Health

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protein arginylation

Papers overview

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Highly Cited
2012
Highly Cited
2012
Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to…
A consistent clinical feature of amyotrophic lateral sclerosis (ALS) is the sparing of eye movements and the function of external… 
Highly Cited
2007
Highly Cited
2007
The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.
Notch signaling is of crucial importance in normal T-cell development and Notch 1 is frequently mutated in T-cell acute… 
Highly Cited
2004
Highly Cited
2004
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice.
Muscle wasting accompanies aging and pathological conditions ranging from cancer, cachexia, and diabetes to denervation and… 
Review
2004
Review
2004
Aurora A, Meiosis and Mitosis
Highly Cited
2000
Highly Cited
2000
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression.
The c-Myc oncoprotein plays an important role in the growth and proliferation of normal and neoplastic cells. To execute these… 
Highly Cited
1998
Highly Cited
1998
mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway.
Upon activation in response to cellular stress or DNA damage, the p53 tumor suppressor induces the expression of gene products… 
Highly Cited
1996
Highly Cited
1996
In vivo ubiquitination and proteasome-mediated degradation of p53(1).
The levels of the tumor suppressor protein p53 are generally quite low in normal cells, due in part to its rapid turnover… 
Highly Cited
1996
Highly Cited
1996
Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.
Recent studies suggest that sepsis-induced increase in muscle proteolysis mainly reflects energy-ubiquitin-dependent protein… 
Highly Cited
1995
Highly Cited
1995
Amyloid β-Protein Inhibits Ubiquitin-dependent Protein Degradation in Vitro(*)
Intraneuronal accumulation of ubiquitin conjugates in inclusion bodies and neurofibrillary tangles is a pathological feature of… 
Highly Cited
1994
Highly Cited
1994
Interferon-gamma induces different subunit organizations and functional diversity of proteasomes.
To obtain information on the role of proteasomes in the immune system, we examined the effect of a major immunomodulatory… 
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