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tyrphostin A23

Known as: 3,4-dihydroxybenzylidenemalononitrile, 18 aged, (3,4-dihydroxybenzylidene)malononitrile 
A broad spectrum protein tyrosine kinase inhibitor that inhibits epidermal growth factor receptor, GTPase activity of transducin, aldosterone… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (3)

Antineoplastic AgentsEnzyme InhibitorsTyrphostins
Receptor Tyrosine Kinase Inhibitiontyrphostin A1

Papers overview

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Highly Cited
2006
Highly Cited
2006
Airway hyper‐responsiveness in allergic asthma in guinea‐pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA
Background: The neurotrophin nerve growth factor (NGF) has been implicated as a mediator in allergic asthma. Direct evidence that… 
Highly Cited
2004
Highly Cited
2004
The Human Papillomavirus Type 16 E5 Protein Modulates ERK1/2 and p38 MAP Kinase Activation by an EGFR-Independent Process in Stressed Human Keratinocytes
The human papillomavirus type 16 E5 gene product has been shown to upregulate the activation of MAP kinases ERK1/2 and cellular… 
2003
2003
Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine…
Recent data suggest that G protein-coupled receptors (GPCRs), including those for PTH and prostaglandins (PGs), contribute to the… 
Highly Cited
2001
Highly Cited
2001
Growth hormone signalling and apoptosis in neonatal rat cardiomyocytes
Growth hormone (GH) has been reported to be useful to treat heart failure. To elucidate whether GH has direct beneficial effects… 
1999
1999
Protein tyrosine kinase‐dependent release of intracellular calcium in the sea urchin egg
The aminoguanide, methylglyoxal bis(guanylhydrazone) (MGBG), was shown to stimulate phosphorylation of RR‐SRC, a synthetic… 
Highly Cited
1999
Highly Cited
1999
[3H]taurine andd-[3H]aspartate release from astrocyte cultures are differently regulated by tyrosine kinases.
Volume-dependent anion channels permeable for Cl- and amino acids are thought to play an important role in the homeostasis of… 
Highly Cited
1996
Highly Cited
1996
Effects of EGF on alveolar epithelial junctional permeability and active sodium transport.
We evaluated the effects of epidermal growth factor (EGF) on transepithelial resistance (Rt) and active ion transport by alveolar… 
Highly Cited
1996
Highly Cited
1996
Induction of c-jun protooncogene expression by hydrogen peroxide through hydroxyl radical generation and p60SRC tyrosine kinase activation.
Highly Cited
1995
Highly Cited
1995
Characterization of a volume‐sensitive chloride current in rat osteoblast‐like (ROS 17/2.8) cells.
1. During osmotic swelling, cultured osteoblastic cells (ROS 17/2.8) exhibited activation of large amplitude Cl‐ currents in the… 
Highly Cited
1993
Highly Cited
1993
Tyrosine kinases and phosphoinositide metabolism in thrombin-stimulated human platelets.
In this study we have examined the implication of tyrosine kinase activities in aggregation, 5-hydroxytryptamine secretion and… 
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