tyrphostin A23

Known as: 3,4-dihydroxybenzylidenemalononitrile, 18 aged, (3,4-dihydroxybenzylidene)malononitrile 
A broad spectrum protein tyrosine kinase inhibitor that inhibits epidermal growth factor receptor, GTPase activity of transducin, aldosterone… (More)
National Institutes of Health

Related topics

Related topics

5 relations

Broader (3)

Antineoplastic AgentsEnzyme InhibitorsTyrphostins
Receptor Tyrosine Kinase Inhibitiontyrphostin A1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1
The objective of the present study was to investigate the effect of leptin, alone or in combination with IL-1, on nitric oxide… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release.
The mechanisms underlying caspase-1 activation and IL-1beta processing during inflammatory activation of monocytes and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Tyrphostin A23 inhibits internalization of the transferrin receptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex.
Several intracellular membrane trafficking events are mediated by tyrosine-containing motifs within the cytosolic domains of… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor.
Cannabinoids, the active components of marijuana and their endogenous counterparts, exert many of their actions in brain through… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway.
OBJECTIVES Ghrelin is a brain-gut peptide with GH-releasing and appetite-inducing activities and a widespread tissue distribution… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells.
The receptor for insulin-like growth factor 1 (IGF-1) mediates multiple cellular responses, including stimulation of both… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells.
Overexpression of interleukin 6, a downstream target of the GBX2 homeobox gene, has been linked to the progression of prostate… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases.
G protein-coupled receptors (GPCRs) initiate Ras-dependent activation of the Erk 1/2 mitogen-activated protein kinase cascade by… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival.
Adhesion of human primary skin fibroblasts and ECV304 endothelial cells to immobilized matrix proteins, beta1 or alphav integrin… (More)
  • figure 1
  • figure 3
  • figure 2
  • figure 5
  • figure 4
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines.
Mycosis fungoides (MF) is a low-grade cutaneous T cell lymphoma of unknown etiology. In this report, the Jak/Stat (Janus kinase… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?