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tyrphostin A23
Known as:
3,4-dihydroxybenzylidenemalononitrile
, 18 aged
, (3,4-dihydroxybenzylidene)malononitrile
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A broad spectrum protein tyrosine kinase inhibitor that inhibits epidermal growth factor receptor, GTPase activity of transducin, aldosterone…
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National Institutes of Health
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Related topics
Related topics
5 relations
Broader (3)
Antineoplastic Agents
Enzyme Inhibitors
Tyrphostins
Receptor Tyrosine Kinase Inhibition
tyrphostin A1
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Airway hyper‐responsiveness in allergic asthma in guinea‐pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA
A. D. Vries
,
F. Engels
,
+7 authors
Axel Fischer
Clinical and Experimental Allergy
2006
Corpus ID: 23886894
Background: The neurotrophin nerve growth factor (NGF) has been implicated as a mediator in allergic asthma. Direct evidence that…
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Highly Cited
2004
Highly Cited
2004
The Human Papillomavirus Type 16 E5 Protein Modulates ERK1/2 and p38 MAP Kinase Activation by an EGFR-Independent Process in Stressed Human Keratinocytes
K. Crusius
,
I. Rodríguez
,
A. Alonso
Virus genes
2004
Corpus ID: 35975531
The human papillomavirus type 16 E5 gene product has been shown to upregulate the activation of MAP kinases ERK1/2 and cellular…
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2003
2003
Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine…
Intekhab Ahmed
,
D. Gesty‐Palmer
,
M. Drezner
,
L. Luttrell
Molecular Endocrinology
2003
Corpus ID: 25578915
Recent data suggest that G protein-coupled receptors (GPCRs), including those for PTH and prostaglandins (PGs), contribute to the…
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Highly Cited
2001
Highly Cited
2001
Growth hormone signalling and apoptosis in neonatal rat cardiomyocytes
Yaping Gu
,
Y. Zou
,
+8 authors
I. Komuro
Molecular and Cellular Biochemistry
2001
Corpus ID: 38227186
Growth hormone (GH) has been reported to be useful to treat heart failure. To elucidate whether GH has direct beneficial effects…
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1999
1999
Protein tyrosine kinase‐dependent release of intracellular calcium in the sea urchin egg
S. Shen
,
W. Kinsey
,
Shyh-Jye Lee
Development, Growth and Differentiation
1999
Corpus ID: 21624797
The aminoguanide, methylglyoxal bis(guanylhydrazone) (MGBG), was shown to stimulate phosphorylation of RR‐SRC, a synthetic…
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Highly Cited
1999
Highly Cited
1999
[3H]taurine andd-[3H]aspartate release from astrocyte cultures are differently regulated by tyrosine kinases.
A. A. Mongin
,
J. Reddi
,
C. Charniga
,
H. Kimelberg
American Journal of Physiology - Cell Physiology
1999
Corpus ID: 4518510
Volume-dependent anion channels permeable for Cl- and amino acids are thought to play an important role in the homeostasis of…
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Highly Cited
1996
Highly Cited
1996
Effects of EGF on alveolar epithelial junctional permeability and active sodium transport.
Z. Borok
,
A. Hami
,
S. Danto
,
R. Lubman
,
Kwang-Jin Kim
,
E. Crandall
American Journal of Physiology
1996
Corpus ID: 19602801
We evaluated the effects of epidermal growth factor (EGF) on transepithelial resistance (Rt) and active ion transport by alveolar…
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Highly Cited
1996
Highly Cited
1996
Induction of c-jun protooncogene expression by hydrogen peroxide through hydroxyl radical generation and p60SRC tyrosine kinase activation.
Shern-Fwu Lee
,
Ying‐tang Huang
,
W. Wu
,
Jen-kun Lin
Free Radical Biology & Medicine
1996
Corpus ID: 19800808
Highly Cited
1995
Highly Cited
1995
Characterization of a volume‐sensitive chloride current in rat osteoblast‐like (ROS 17/2.8) cells.
M. Gosling
,
J. Smith
,
D. Poyner
Journal of Physiology
1995
Corpus ID: 23020792
1. During osmotic swelling, cultured osteoblastic cells (ROS 17/2.8) exhibited activation of large amplitude Cl‐ currents in the…
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Highly Cited
1993
Highly Cited
1993
Tyrosine kinases and phosphoinositide metabolism in thrombin-stimulated human platelets.
C. Guinebault
,
B. Payrastre
,
+5 authors
H. Chap
Biochemical Journal
1993
Corpus ID: 36242475
In this study we have examined the implication of tyrosine kinase activities in aggregation, 5-hydroxytryptamine secretion and…
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