tuberous sclerosis complex 2 protein

Known as: TSC2, Tuberin, Tuberous Sclerosis 2 Protein 
Tuberin has sequence similarity to the GTPase-activating protein GAP3 and may regulate cell growth. It specifically stimulates the GTPase activity of… (More)
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
OBJECTIVE Epilepsy is a major manifestation of tuberous sclerosis complex (TSC). Everolimus is an mammalian target of rapamycin… (More)
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Review
2008
Review
2008
Tuberous sclerosis is a genetic multisystem disorder characterised by widespread hamartomas in several organs, including the… (More)
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Review
2005
Review
2005
The most exciting advances in the tuberous sclerosis complex (TSC) field occurred in 1993 and 1997 with the cloning of the TSC2… (More)
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Highly Cited
2004
Highly Cited
2004
Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in either of the two tumor suppressor genes TSC1 or… (More)
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Review
2004
Review
2004
The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy status. Whenever the cellular ATP:ADP ratio falls… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Tuberous Sclerosis Complex (TSC) is a genetic disorder that occurs through the loss of heterozygosity of either TSC1… (More)
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Highly Cited
2003
Highly Cited
2003
The tuberous sclerosis complex (TSC) is a genetic disorder that is caused through mutations in either one of the two tumor… (More)
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Highly Cited
2002
Highly Cited
2002
The S/T-protein kinases activated by phosphoinositide 3-kinase (PI3K) regulate a myriad of cellular processes. Here, we show that… (More)
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Highly Cited
2002
Highly Cited
2002
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that occurs upon mutation of either the TSC1 or TSC2… (More)
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Review
2001
Review
2001
In the cerebrum of patients with tuberous sclerosis (TSC), there are three types of nodular lesions: cortical tubers, subcortical… (More)
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