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trypsinogen activation

Known as: cleavage of trypsinogen to trypsin 
The proteolytic processing of trypsinogen to the active form, trypsin. [GOC:mah]
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND & AIMS The signaling mechanisms that regulate trypsinogen activation and inflammation in acute pancreatitis (AP) are… Expand
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Highly Cited
2011
Highly Cited
2011
BACKGROUND & AIMS The role of trypsinogen activation in the pathogenesis of acute pancreatitis (AP) has not been clearly… Expand
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Highly Cited
2006
Highly Cited
2006
Trypsin-mediated trypsinogen activation (autoactivation) facilitates digestive zymogen activation in the duodenum but may… Expand
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Highly Cited
2003
Highly Cited
2003
The activation peptide of mammalian trypsinogens contains a highly conserved tetra-aspartate sequence (D19-D20-D21-D22) preceding… Expand
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Highly Cited
2002
Highly Cited
2002
The lysosomal cysteine protease cathepsin B is thought to play a central role in intrapancreatic trypsinogen activation and the… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND & AIMS Prior thermal stress induces heat shock protein 70 (HSP70) expression in the pancreas and protects against… Expand
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Highly Cited
2001
Highly Cited
2001
Intra-acinar cell nuclear factor-kappaB (NF-kappaB) and trypsinogen activation are early events in secretagogue-induced acute… Expand
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Highly Cited
2000
Highly Cited
2000
Rodents given a supramaximally stimulating dose of cholecystokinin or its analogue cerulein develop acute pancreatitis with… Expand
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Highly Cited
1999
Highly Cited
1999
Enteropeptidase is a membrane-bound serine protease that initiates the activation of pancreatic hydrolases by cleaving and… Expand
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Highly Cited
1988
Highly Cited
1988
Tetra-L-aspartyl-L-lysine (D4K) containing trypsinogen activation peptides were synthesised on solid-phase supports. Synthetic… Expand
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