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tryparedoxin peroxidase

National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
ABSTRACT The clinical value of antimonial drugs, the mainstay therapy for leishmaniasis, is now threatened by the emergence of… Expand
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2008
2008
Antioxidant defense in Trypanosomatids has been indicated as a potential target for chemotherapy. Tryparedoxin peroxidase (TXNPx… Expand
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2006
2006
Parasites of the Leishmania Viannia subgenus are major causative agents of mucocutaneous leishmaniasis (MCL), a disease… Expand
2006
2006
ABSTRACT Leishmaniasis affects 12 million people, but there are no vaccines in routine clinical use. Th1 polarizing vaccines that… Expand
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Highly Cited
2005
Highly Cited
2005
Leishmaniasis affects 12 million people, but there are no vaccines. Immunological correlates of vaccine efficacy are unclear… Expand
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Highly Cited
2001
Highly Cited
2001
In trypanosomatids, removal of hydrogen peroxide and other aryl and alkyl peroxides is achieved by the NADPH-dependent… Expand
Highly Cited
2000
Highly Cited
2000
Tryparedoxin peroxidase (TryP) is a recently discovered 2Cys-peroxiredoxin involved in defence against oxidative stress in… Expand
Highly Cited
1999
Highly Cited
1999
Tryparedoxin peroxidase (TXNPx), recently identified as the hydroperoxide-detoxifying enzyme of trypanosomatidae [Nogoceke, E… Expand
1998
1998
As a consequence of aerobic metabolism, trypanosomatids are exposed to reactive oxygen intermediates such as superoxide, hydrogen… Expand
Highly Cited
1998
Highly Cited
1998
Leishmania spp. encounter damaging oxygen metabolites from endogenous metabolic processes as well as from exogenous sources, such… Expand