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tropomyosin-related kinase-B, human

Known as: TrkB protein, human, Tropomyosin-Related Kinase B, NTRK2 protein, human 
BDNF/NT-3 growth factors receptor (822 aa, ~92 kDa) is encoded by the human NTRK2 gene. This protein plays a role in growth factor-dependent… 
National Institutes of Health

Related topics

Related topics

26 relations
Cell Differentiation processCell ProliferationEnzyme GeneImmunoglobulin C2-set Domain

Broader (2)

Membrane GlycoproteinsProtein Tyrosine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Potential therapeutic uses of BDNF in neurological and psychiatric disorders
The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TRKB) are… 
Review
2007
Review
2007
New insights into BDNF function in depression and anxiety
The 'neurotrophin hypothesis of depression' is based largely on correlations between stress or antidepressant treatment and down… 
Highly Cited
2003
Highly Cited
2003
Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects
Recent studies have indicated that exogenously administered neurotrophins produce antidepressant-like behavioral effects. We have… 
Highly Cited
2001
Highly Cited
2001
Infusion of Brain-Derived Neurotrophic Factor into the Lateral Ventricle of the Adult Rat Leads to New Neurons in the Parenchyma of the Striatum, Septum, Thalamus, and Hypothalamus
The findings that brain-derived neurotrophic factor (BDNF) promotes in vitro the survival and/or differentiation of postnatal… 
Highly Cited
1999
Highly Cited
1999
Essential Role for TrkB Receptors in Hippocampus-Mediated Learning
Highly Cited
1996
Highly Cited
1996
Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus
NEUROTROPHINS promote neuronal survival and differentiation, but the fact that their expression is modified by neuronal activity… 
Highly Cited
1996
Highly Cited
1996
Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus
The present study demonstrates that chronic, but not acute, adminstration of several different classes of antidepressants… 
Highly Cited
1994
Highly Cited
1994
Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development
Highly Cited
1991
Highly Cited
1991
The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
Highly Cited
1991
Highly Cited
1991
Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB
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