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The interference of bile acid secretion through bile salt export pump (BSEP) inhibition is one of the mechanisms for troglitazone… Expand The bile salt export pump (BSEP) plays an important role in bile acid excretion. Impaired BSEP function may result in liver… Expand This study examined the hepatobiliary disposition of troglitazone (TGZ) and metabolites [TGZ sulfate (TS), TGZ glucuronide (TG… Expand Hepatic uptake carriers of the organic anion-transporting peptide (OATP) family of solute carriers are more and more recognized… Expand Troglitazone sulfate (TGZS) is the major metabolite of troglitazone (TGZ), an antidiabetic agent, and thought to be a cause of… Expand Troglitazone is a thiazolidinedione insulin sensitizer drug that is metabolized mainly to a sulfate conjugate (M-1) in humans. It… Expand Troglitazone is a thiazolidinedione insulin sensitizer drug for the treatment of type 2 non-insulin-dependent diabetes mellitus… Expand We investigated whether lack of the canalicular multispecific organic anion transporter in transport-deficient (TR-) rats would… Expand In primary human and porcine hepatocyte cultures, we investigated the relationship between metabolism and cytotoxicity of… Expand Troglitazone, a PPAR-gamma agonist, enhances the actions of insulin on muscle and liver. It is metabolized predominantly in the… Expand