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trimethylcolchicinic acid
Known as:
Colchicinic Acid, Trimethyl-
, (S)-7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxybenzo(a)heptalen-9(5H)-one
, TMCA
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A colchicine analog with potential antineoplastic activity. Trimethylcolchicinic acid binds to tubulin, inhibiting its polymerization into…
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National Institutes of Health
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Related topics
Related topics
6 relations
Broader (2)
Colchicine
Methyl Ethers
Microtubule Process
analogs & derivatives
trimethylcolchicinic acid methyl ether
Narrower (1)
trimethylcolchicinic acid methyl ether d-tartrate
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Platform Construction and Application Research Based on the Smarter Tourism TMCA System
Dai Li
2016
Corpus ID: 51999317
Domestic scenic spots during the golden week holiday lots of passengers flow and the scenic spot service behind the conflict in…
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2014
2014
Analyzing App Inventor for Building Usable Touch Screen Courseware for Blind Users
M. Fakrudeen
,
S. Yousef
,
A. Hussein
2014
Corpus ID: 51570585
This paper focuses on how to design and develop a usable Touch Screen Mobile Courseware Application (TMCA) by using usability…
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2011
2011
Objective Evaluation of Nasal Dimensions in Children with Acoustic Rhinometry
L. Haavisto
2011
Corpus ID: 38280831
Lotta Haavisto. Objective evaluation of nasal dimensions in children with acoustic rhinometry. The Department of…
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1986
1986
Influence of urinary sodium excretion on the clinical assessment of renal tubular calcium reabsorption in hypercalcaemic man.
S. Ralston
,
M. D. Gardner
,
F. Dryburgh
,
R. Cowan
,
I. Boyle
Journal of Clinical Pathology
1986
Corpus ID: 16139179
The relation between urinary sodium excretion (NaE) and renal tubular calcium reabsorption (TmCa/GFR) was assessed in patients…
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1983
1983
[Biliary excretion of choleretically active cinnamic acid derivatives in the rat].
J. Westendorf
,
G. Czok
Zeitschrift für Ernährungswissenschaft
1983
Corpus ID: 32615169
Concerning the well-known choleretic effect of ferulic acid, we made further investigations on biliary excretion, metabolism and…
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1979
1979
The binding of colchicine and its derivatives to bovine and human serum albumin and human plasma.
Z. Trnavská
,
M. Kuchař
,
V. Rejholec
,
K. Trnavský
Pharmacology
1979
Corpus ID: 3293933
The protein binding of colchicine and its derivatives demecolcine and desacetylcolchiceine was studied by equilibrium dialysis at…
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1979
1979
Microbial transformations and 13C-NMR analysis of colchicine.
C. D. Hufford
,
C. C. Collins
,
A. Clark
Journal of Pharmacy and Science
1979
Corpus ID: 39713778
Several microorganisms were screened for their ability to biotransform colchicine, and two were selected for preparative scale…
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1976
1976
Effect of trimethylcolchicinic acid methyl ether d-tartrate (TMCA) on Hodgkin's and non-Hodgkin's lymphoma.
D. Stolinsky
,
E. Jacobs
,
L. Irwin
,
T. Pajak
,
J. Bateman
Oncology
1976
Corpus ID: 46881331
Trimethylcolchicinic acid methyl ether d-tartrate (TMCA; NSC-36351) was administered daily by mouth to 71 patients with malignant…
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1975
1975
Metabolic transformation of colchicine, III. Inhibition of phosphatases by the metabolite O10-demethylcolchicine (colchiceine) and their reactivation by divalent cations.
G. Siebert
,
M. Schönharting
,
M. Ott
,
S. Surjana
Hoppe-Seyler´s Zeitschrift für physiologische…
1975
Corpus ID: 6089777
Colchicine and some of its metabolites and derivatives were investigated regarding their inhibitory action against alkaline…
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1952
1952
Damage induced in sarcoma 37 with chemical agents. III. Colchicine derivatives related to trimethylcolchicinic acid and to colchinol.
J. Leiter
,
V. Downing
,
J. Hartwell
,
M. J. Shear
Journal of the National Cancer Institute
1952
Corpus ID: 43394537