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trimethylcolchicinic acid methyl ether

Known as: desacetylcolchicine, (S)-7-amino-6,7-dihydro-1,2,3,10-tetramethoxybenzo(a)heptalen-9(5H)-one, N-deacetylcolchiceine 
National Institutes of Health

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Broader (1)

Colchicine

Narrower (1)

NSC-36354
analogs & derivativestrimethylcolchicinic acid

Papers overview

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2009
2009
Killing and characterizing action of colchicine in vitro on lymphocytes of chronic lymphocytic leukaemia.
Circulating lymphocytes in chronic lymphocytic leukaemia (CLL) that die in vitro in 1 day of culture with 10-7M-colchicine (0.04… 
1991
1991
Deacetylcolchicine derivatives, process for preparation thereof, and antitumor composition
FIELD: medicine, as antitumor compound. SUBSTANCE: product: deacetylcolchicine derivative of formula i wherein R is C(O) acyl… 
1986
1986
Hydrophobic chromatography of tubulin on immobilized colchicine columns with various spacers.
Eleven immobilized-colchicine adsorbents were synthesized from deacetylcolchicine (DAC) and Sepharose with various spacers (R… 
1984
1984
Immobilization-dependent fluorescence of colchicine.
Colchicine fluoresces when bound to tubulin but not in water, dioxane, or benzene. The basis of the fluorescence has now been… 
1983
1983
Biological effects of modified colchicines. 2. Evaluation of catecholic colchicines, colchifolines, colchicide, and novel N-acyl- and N-aroyldeacetylcolchicines.
A series of natural and synthetic colchicine derivatives was examined for their potency in the lymphocytic leukemia P388 screen… 
1982
1982
Deacetylcolchicine conjugated to a heme-nonapeptide act with both soluble tubulin and microtubules polymerized in vitro.
A heme-nonapeptide with peroxidase-like activity was conjugated to pure deacetylcolchicine. This conjugated colchicine derivative… 
1972
1972
Desacetylcolchicine and desacetylcolchiceine — New alkaloids from Merendera robusta
1962
1962
Studies on colchicine, colchicine derivatives, and endotoxin in irradiated animals.
Colchicine when given 3, 2, or 1 day and trimethylcolchicinic acid methyl ether, colchiceinamide, colchiceine, and N… 
1956
1956
[Glutathione content of Yoshida-ascites-sarcoma-bearing rats during treatment with deacetylcolchicine by itself and in combination with hydrocortisone and ACTH].
1955
1955
[Experimental study and first clinical application of a colchicine derivative with antiblastic action: methyl ester of trimethylcolchicinic acid (deacetylcolchicine)].