tremelimumab

Known as: Anti-CTLA4 Human Monoclonal Antibody CP-675,206, Immunoglobulin G2, Anti-(Human CTLA-4 (Antigen)) (Human Monoclonal CP-675206 Clone 11.2.1 Heavy Chain) Disulfide with Human Monoclonal CP-675206 Clone 11.2.1 Light Chain, Dimer, Ticilimumab 
A human IgG2 monoclonal antibody directed against the T-cell receptor protein cytotoxic T-lymphocyte-associated protein 4 (CTLA4). Tremelimumab binds… (More)
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
BACKGROUND PD-L1 and CTLA-4 immune checkpoints inhibit antitumour T-cell activity. Combination treatment with the anti-PD-L1… (More)
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Highly Cited
2014
Highly Cited
2014
Alexandra Snyder, M.D., Vladimir Makarov, M.D., Taha Merghoub, Ph.D., Jianda Yuan, M.D., Ph.D., Jesse M. Zaretsky, B.S., Alexis… (More)
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Highly Cited
2014
Highly Cited
2014
Cytotoxic T lymphocyte antigen–4 (CTLA-4) is an inhibitory receptor found on immune cells. The consequences of mutations in CTLA4… (More)
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Highly Cited
2013
Highly Cited
2013
PURPOSE In phase I/II trials, the cytotoxic T lymphocyte-associated antigen-4-blocking monoclonal antibody tremelimumab induced… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND & AIMS Tremelimumab is a monoclonal antibody that blocks cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), an… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Monoclonal antibodies to cytotoxic T-lymphocyte antigen 4 (CTLA4) have therapeutic activity in different tumour types… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Tremelimumab is a fully human monoclonal antibody specific for CTL-associated antigen 4 (CTLA4) with single-agent… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Cytotoxic T lymphocyte antigen 4 (CTLA4), a key negative regulator of T-cell activation, is targeted by the antibody… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE Cytotoxic T lymphocyte-associated antigen 4 (CTLA4) blockade with tremelimumab (CP-675,206), a fully human anti-CTLA4… (More)
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Review
2007
Review
2007
Tremelimumab (CP-675,206) is a fully human monoclonal antibody specific for human cytotoxic T lymphocyte-associated antigen 4… (More)
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