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trefoil factor

Known as: Trefoil Proteins, Trefoil Factor Family Peptides, Trefoil Factors [Chemical/Ingredient] 
A family of small peptides expressed primarily by MUCOUS MEMBRANE EPITHELIAL CELLS in vertebrates. Their structure is highly conserved and is defined… Expand
National Institutes of Health

Papers overview

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Review
2010
Review
2010
The mucus layer coating the gastrointestinal tract is the front line of innate host defense, largely because of the secretory… Expand
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Highly Cited
2007
Highly Cited
2007
Trefoil factors (TTFs) are small, compact proteins coexpressed with mucins in the gastrointestinal tract. Three trefoil factors… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND & AIMS Expression of mucin MUC2, the structural component of the colonic mucus layer, is lowered in inflammatory bowel… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND & AIMS Effective therapeutics for treating acute colitis, caused by disruption of the intestinal epithelial barrier… Expand
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Review
2003
Review
2003
Maintaining the integrity of the gastrointestinal tract, despite the continual presence of microbial flora and injurious agents… Expand
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Highly Cited
2002
Highly Cited
2002
The intracellular signaling mechanisms that specify tissue-specific responses to the interleukin-6 (IL-6) family of cytokines are… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Trefoil peptides (TFFs) are expressed and secreted in a tissue-specific manner in the gastrointestinal tract. Evidence… Expand
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Highly Cited
2001
Highly Cited
2001
Mucosal organs such as the intestine are supported by a rich and complex underlying vasculature. For this reason, the intestine… Expand
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Highly Cited
2000
Highly Cited
2000
Intestinal trefoil factor (ITF) is an essential regulator of colonic epithelial restitution, the rapid migration of colonocytes… Expand
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Highly Cited
1996
Highly Cited
1996
The mechanisms that maintain the epithelial integrity of the gastrointestinal tract remain largely undefined. The gene encoding… Expand
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