Skip to search formSkip to main contentSkip to account menu

trapoxin A

Known as: Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl), Cyclo((S)-gamma-oxo-L-alpha-aminooxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-D-2-piperidinecarbonyl), Trapoxin 
An epoxide-containing cyclotetrapeptide with antitumor activity. It is an irreversible inhibitor of histone deacetylase.
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

Antibiotics, AntineoplasticHistone deacetylase inhibitorPeptides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Histone Deacetylase Inhibitor (Trapoxin A) Enhances Stemness Properties in Adipose Tissue Derived Mesenchymal Stem Cells
Abstract Back ground Adipose tissue derived mesenchymal stem cells (ASCs) have unique potential for regenerative cell therapies… 
2012
2012
Ribosomally encoded cyclic peptide toxins from mushrooms.
2008
2008
c[D‐pro‐Pro‐D‐pro‐N‐methyl‐Ala] adopts a rigid conformation that serves as a scaffold to mimic reverse‐turns
Naturally occurring cyclic tetrapeptides (CTPs) such as tentoxin (Halloin et al., Plant Physiol 1970, 45, 310–314; Saad… 
Review
2008
Review
2008
Histone deacetylase inhibitors from microorganisms: the Astellas experience.
Histone deacetylase (HDAC) inhibitors, such as trichostatin A and trapoxin, which were first found in microorganisms, potently… 
1999
1999
Cooperation between Phosphorylation and Acetylation Processes in Transcriptional Control
ABSTRACT We previously reported that the activation of the M promoter of the human choline acetyltransferase (ChAT) gene by… 
1998
1998
Activation of the MAP kinase cascade by histone deacetylase inhibitors is required for the stimulation of choline acetyltransferase gene promoter.
1998
1998
Characterization of a human RPD 3 ortholog , HDAC 3
Histone acetylation levels in cells result from a dynamic equilibrium between competing histone acetylases and deacetylases… 
Highly Cited
1997
Highly Cited
1997
Induction of gamma-globin by histone deacetylase inhibitors.
The short-chain fatty acid butyrate has been shown to elevate fetal hemoglobin (HbF) by inducing expression of the gamma-globin… 
1997
1997
Induction of g-Globin by Histone Deacetylase Inhibitors
The short-chain fatty acid butyrate has been shown to eleement spanning the duplicated CCAAT box region of the gglobin promoter… 
1996
1996
Histone hyperacetylating agents stimulate promoter activity of human choline acetyltransferase gene in transfection experiment.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)