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transforming growth factor(alpha)-Pseudomonas aeruginosa exotoxin (38)

Known as: TGFalpha-P aeruginosa exotoxin (38), TGFa-PE38 immunotoxin, TP-38 
A recombinant, chimeric toxin composed of human transforming growth factor alpha (TGF-alpha) fused to a fragment of Pseudomonas exotoxin (PE38… 
National Institutes of Health

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ExotoxinsTransforming Growth Factor alpha

Papers overview

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2012
2012
Distinct cellular responses induced by saporin and a transferrin–saporin conjugate in two different human glioblastoma cell lines
Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults, with a median survival of ∼12–18 months post… 
Highly Cited
2008
Highly Cited
2008
Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.
The purpose of this study is to determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and intracerebral… 
Review
2006
Review
2006
Clinical studies with targeted toxins in malignant glioma.
Targeted toxins represent a new class of agents with high specificity for tumor cells. Toxins in current clinical use for the… 
2006
2006
carcinogenesis . alpha in experimental gastric Expression of transforming growth factor
The induction of adenocarcinomas in the glandular stomach of the adult male Wistar rat by N-methyl-N'-nitro-N-nitrosoguanidine… 
2006
2006
TGFalfa, EGFR and p70S6K expression in aggressive colorectal cancer (CRC).
13505 Background: Autocrine TGFa in CRC cells regulates cell adhesion via p70S6K phosphorylation in in vitro studies. The aim was… 
Highly Cited
2005
Highly Cited
2005
Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study.
Glioblastoma multiforme remains refractory to conventional therapy, and novel therapeutic modalities are desperately needed. TP… 
Highly Cited
2003
Highly Cited
2003
Progress Report of a Phase I Study of the Intracerebral Microinfusion of a Recombinant Chimeric Protein Composed of Transforming Growth Factor (TGF)-α and a Mutated form of the Pseudomonas Exotoxin…
TP-38 is a recombinant chimeric targeted toxin composed of the EGFR binding ligand TGF-α and a genetically engineered form of the… 
2003
2003
Gateways to clinical trials.
Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the… 
1999
1999
Induction of apoptosis in human hepatic carcinoma cell line SMMC-7721 by TGFa-PE40
Objective To study the effect of recombinant transforming growth factor α-Pseudomonas exotoxin fusion protein (TGFα-PE40,TP40) on… 
1997
1997
Furin-mediated Cleavage of Pseudomonas Exotoxin-derived Chimeric Toxins*
Pseudomonas exotoxin (PE) requires proteolytic cleavage to generate a 37-kDa C-terminal fragment that translocates to the cytosol… 
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