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transforming growth factor(alpha)-Pseudomonas aeruginosa exotoxin (38)
Known as:
TGFalpha-P aeruginosa exotoxin (38)
, TGFa-PE38 immunotoxin
, TP-38
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A recombinant, chimeric toxin composed of human transforming growth factor alpha (TGF-alpha) fused to a fragment of Pseudomonas exotoxin (PE38…
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National Institutes of Health
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Related topics
Related topics
3 relations
Narrower (1)
Cervene
Broader (2)
Exotoxins
Transforming Growth Factor alpha
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Distinct cellular responses induced by saporin and a transferrin–saporin conjugate in two different human glioblastoma cell lines
A. Cimini
,
S. Mei
,
+11 authors
R. Ippoliti
Journal of Cellular Physiology
2012
Corpus ID: 23136942
Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults, with a median survival of ∼12–18 months post…
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Highly Cited
2008
Highly Cited
2008
Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.
J. Sampson
,
G. Akabani
,
+16 authors
D. Bigner
Neuro-Oncology
2008
Corpus ID: 20984564
The purpose of this study is to determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and intracerebral…
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Review
2006
Review
2006
Clinical studies with targeted toxins in malignant glioma.
N. Rainov
,
A. Söling
Reviews on recent clinical trials
2006
Corpus ID: 25691638
Targeted toxins represent a new class of agents with high specificity for tumor cells. Toxins in current clinical use for the…
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2006
2006
carcinogenesis . alpha in experimental gastric Expression of transforming growth factor
J. Livingstone
,
M. Filipe
,
C. Wastell
2006
Corpus ID: 31013405
The induction of adenocarcinomas in the glandular stomach of the adult male Wistar rat by N-methyl-N'-nitro-N-nitrosoguanidine…
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2006
2006
TGFalfa, EGFR and p70S6K expression in aggressive colorectal cancer (CRC).
M. Tampellini
,
M. Longo
,
+7 authors
M. Papotti
Journal of Clinical Oncology
2006
Corpus ID: 43825701
13505 Background: Autocrine TGFa in CRC cells regulates cell adhesion via p70S6K phosphorylation in in vitro studies. The aim was…
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Highly Cited
2005
Highly Cited
2005
Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study.
J. Sampson
,
D. Reardon
,
+5 authors
D. Bigner
Neuro-Oncology
2005
Corpus ID: 32397799
Glioblastoma multiforme remains refractory to conventional therapy, and novel therapeutic modalities are desperately needed. TP…
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Highly Cited
2003
Highly Cited
2003
Progress Report of a Phase I Study of the Intracerebral Microinfusion of a Recombinant Chimeric Protein Composed of Transforming Growth Factor (TGF)-α and a Mutated form of the Pseudomonas Exotoxin…
J. Sampson
,
G. Akabani
,
+22 authors
I. Pastan
Journal of Neuro-Oncology
2003
Corpus ID: 8126195
TP-38 is a recombinant chimeric targeted toxin composed of the EGFR binding ligand TGF-α and a genetically engineered form of the…
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2003
2003
Gateways to clinical trials.
M. Bayes
,
X. Rabasseda
,
J. Prous
Methods and Findings in Experimental and Clinical…
2003
Corpus ID: 32643595
Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the…
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1999
1999
Induction of apoptosis in human hepatic carcinoma cell line SMMC-7721 by TGFa-PE40
C. Xiong
1999
Corpus ID: 88144797
Objective To study the effect of recombinant transforming growth factor α-Pseudomonas exotoxin fusion protein (TGFα-PE40,TP40) on…
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1997
1997
Furin-mediated Cleavage of Pseudomonas Exotoxin-derived Chimeric Toxins*
M. Chiron
,
C. Fryling
,
D. FitzGerald
Journal of Biological Chemistry
1997
Corpus ID: 20363796
Pseudomonas exotoxin (PE) requires proteolytic cleavage to generate a 37-kDa C-terminal fragment that translocates to the cytosol…
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