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transforming growth factor(alpha)-Pseudomonas aeruginosa exotoxin (38)

Known as: TGFalpha-P aeruginosa exotoxin (38), TGFa-PE38 immunotoxin, TP-38 
A recombinant, chimeric toxin composed of human transforming growth factor alpha (TGF-alpha) fused to a fragment of Pseudomonas exotoxin (PE38… 
National Institutes of Health

Papers overview

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2012
2012
Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults, with a median survival of ∼12–18 months post… 
Highly Cited
2008
Highly Cited
2008
The purpose of this study is to determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and intracerebral… 
Review
2006
Review
2006
Targeted toxins represent a new class of agents with high specificity for tumor cells. Toxins in current clinical use for the… 
2006
2006
The induction of adenocarcinomas in the glandular stomach of the adult male Wistar rat by N-methyl-N'-nitro-N-nitrosoguanidine… 
2006
2006
13505 Background: Autocrine TGFa in CRC cells regulates cell adhesion via p70S6K phosphorylation in in vitro studies. The aim was… 
Highly Cited
2005
Highly Cited
2005
Glioblastoma multiforme remains refractory to conventional therapy, and novel therapeutic modalities are desperately needed. TP… 
Highly Cited
2003
Highly Cited
2003
TP-38 is a recombinant chimeric targeted toxin composed of the EGFR binding ligand TGF-α and a genetically engineered form of the… 
2003
2003
Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the… 
1999
1999
Objective To study the effect of recombinant transforming growth factor α-Pseudomonas exotoxin fusion protein (TGFα-PE40,TP40) on… 
1997
1997
Pseudomonas exotoxin (PE) requires proteolytic cleavage to generate a 37-kDa C-terminal fragment that translocates to the cytosol…