transforming growth factor(alpha)-Pseudomonas aeruginosa exotoxin (38)

Known as: TGFalpha-P aeruginosa exotoxin (38), TGFa-PE38 immunotoxin, TP-38 
A recombinant, chimeric toxin composed of human transforming growth factor alpha (TGF-alpha) fused to a fragment of Pseudomonas exotoxin (PE38… (More)
National Institutes of Health

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ExotoxinsTransforming Growth Factor alpha

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2012
2012
Distinct cellular responses induced by saporin and a transferrin-saporin conjugate in two different human glioblastoma cell lines.
Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults, with a median survival of ~12-18 months post… (More)
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Highly Cited
2008
Highly Cited
2008
Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.
The purpose of this study is to determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and intracerebral… (More)
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Review
2006
Review
2006
Clinical studies with targeted toxins in malignant glioma.
Targeted toxins represent a new class of agents with high specificity for tumor cells. Toxins in current clinical use for the… (More)
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2006
2006
carcinogenesis . alpha in experimental gastric Expression of transforming growth factor
The induction of adenocarcinomas in the glandular stomach of the adult male Wistar rat by N-methyl-N'-nitro-N-nitrosoguanidine… (More)
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2005
2005
Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study.
Glioblastoma multiforme remains refractory to conventional therapy, and novel therapeutic modalities are desperately needed. TP… (More)
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2005
2005
0650 Convection enhanced delivery of the targeted toxin TP-38 to malignant brain tumors
  • Journal of the Neurological Sciences
  • 2005
 
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2004
2004
Volume Contents
Introduction to special issue: targeted toxins for glioma therapy R.K. Puri 1–2 Transferrin receptor ligand-targeted toxin… (More)
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Highly Cited
2003
Highly Cited
2003
Progress Report of a Phase I Study of the Intracerebral Microinfusion of a Recombinant Chimeric Protein Composed of Transforming Growth Factor (TGF)-α and a Mutated form of the Pseudomonas Exotoxin…
TP-38 is a recombinant chimeric targeted toxin composed of the EGFR binding ligand TGF-α and a genetically engineered form of the… (More)
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1999
1999
Induction of apoptosis in human hepatic carcinoma cell line SMMC-7721 by TGFa-PE40
 
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1997
1997
Furin-mediated cleavage of Pseudomonas exotoxin-derived chimeric toxins.
Pseudomonas exotoxin (PE) requires proteolytic cleavage to generate a 37-kDa C-terminal fragment that translocates to the cytosol… (More)
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