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transferrin receptor 2, human

Known as: TfR2, Transferrin Receptor Protein 2, Transferrin Receptor 2 
Transferrin receptor protein 2 (801 aa, ~89 kDa) is encoded by the human TFR2 gene. This protein is involved in the mediation of cellular uptake of… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
  • H. Kawabata
  • Free radical biology & medicine
  • 2019
  • Corpus ID: 49674402
ABSTRACT In vertebrates, transferrin (Tf) safely delivers iron through circulation to cells. Tf‐bound iron is incorporated… Expand
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Highly Cited
2009
Highly Cited
2009
The mechanisms that allow the body to sense iron levels in order to maintain iron homeostasis are unknown. Patients with the most… Expand
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Highly Cited
2009
Highly Cited
2009
Hepcidin is a central regulator of iron homeostasis. HFE and transferrin receptor 2 (TFR2) are mutated in adult‐onset forms of… Expand
Highly Cited
2006
Highly Cited
2006
Recently, it has been suggested that hepcidin, a peptide involved in iron homeostasis, is regulated by bone morphogenetic… Expand
Highly Cited
2006
Highly Cited
2006
HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human… Expand
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Highly Cited
2004
Highly Cited
2004
Transferrin receptor 2 (TfR2) is a type 2 transmembrane protein expressed in hepatocytes that binds iron-bound transferrin (Tf… Expand
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Review
2001
Review
2001
  • R. Fleming, W. Sly
  • Proceedings of the National Academy of Sciences…
  • 2001
  • Corpus ID: 32931738
Disorders of iron homeostasis, resulting in iron deficiency or overload, are very common worldwide (1). Normal iron homeostasis… Expand
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Highly Cited
2000
Highly Cited
2000
In most cells, transferrin receptor (TfR1)-mediated endocytosis is a major pathway for cellular iron uptake. We recently cloned… Expand
Highly Cited
2000
Highly Cited
2000
The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein… Expand
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Highly Cited
1999
Highly Cited
1999
Transferrin receptor (TfR) plays a major role in cellular iron uptake through binding and internalizing a carrier protein… Expand
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