transcription-coupled nucleotide-excision repair

Known as: transcription-coupled NER, Transcription-Coupled Repair, TCR 
The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In… (More)
National Institutes of Health

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Review
2008
Review
2008
The encounter of elongating RNA polymerase II (RNAPIIo) with DNA lesions has severe consequences for the cell as this event… (More)
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2004
2004
BACKGROUND Irofulven is a novel alkylating agent with promising clinical activity, particularly toward ovarian and hormone… (More)
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2004
2004
The hepatitis B virus X protein (HBx) is implicated in liver cancer development, and this presumably involves its ability to bind… (More)
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2003
2003
Nucleotide excision repair (NER) prevents skin cancer by eliminating highly genotoxic cyclobutane pyrimidine dimers (CPDs… (More)
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Highly Cited
2002
Highly Cited
2002
The resistance of tumor cells to chemotherapeutic agents, such as cisplatin,is an important problem to be solved in cancer… (More)
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Highly Cited
2001
Highly Cited
2001
While investigating the novel anticancer drug ecteinascidin 743 (Et743), a natural marine product isolated from the Caribbean sea… (More)
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2000
2000
The nucleotide excision repair machinery can be targeted preferentially to lesions in transcribed sequences. This mode of DNA… (More)
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Highly Cited
1998
Highly Cited
1998
The breast and ovarian cancer susceptibility gene BRCA1 encodes a zinc finger protein of unknown function. Association of the… (More)
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Highly Cited
1997
Highly Cited
1997
We have shown previously that Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in the removal of UV… (More)
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Highly Cited
1997
Highly Cited
1997
A mouse model for the nucleotide excision repair disorder Cockayne syndrome (CS) was generated by mimicking a truncation in the… (More)
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