topoisomerase activity

Known as: topoisomerase 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2018
020040019752018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1996
Highly Cited
1996
Several metazoan splicing factors are characterized by ribonucleoprotein (RNP) consensus sequences and arginine-serine repeats… (More)
Is this relevant?
Highly Cited
1989
Highly Cited
1989
Twenty-two compounds related to camptothecin, a known inhibitor of eukaryotic topoisomerase I, were studied. The following… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 4
  • figure 3
Is this relevant?
Highly Cited
1989
Highly Cited
1989
Tyrosine phosphorylation plays a crucial role in cell proliferation and cell transformation which suggests that tyrosine kinase… (More)
  • figure 1
  • figure 3
  • figure 2
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1988
Highly Cited
1988
Camptothecin, a plant alkaloid with antitumor activity, has been shown to be a potent inhibitor of nucleic acid synthesis and a… (More)
  • figure 3
  • figure 1
  • figure 5
  • figure 6
  • figure 4
Is this relevant?
Highly Cited
1985
Highly Cited
1985
Camptothecin, a cytotoxic drug, is a strong inhibitor of nucleic acid synthesis in mammalian cells and a potent inducer of strand… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1985
Highly Cited
1985
We have constructed five new temperature-sensitive DNA topoisomerase II mutations and have analyzed their physiological… (More)
Is this relevant?
Highly Cited
1985
Highly Cited
1985
We have obtained a polyclonal antibody that recognizes a major polypeptide component of chicken mitotic chromosome scaffolds… (More)
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1984
Highly Cited
1984
Adriamycin (doxorubicin), a potent antitumor drug in clinical use, interacts with nucleic acids and cell membranes, but the… (More)
Is this relevant?
Highly Cited
1984
Highly Cited
1984
A temperature-sensitive DNA topoisomerase II mutant of the yeast Saccharomyces cerevisiae has been identified. Genetic analysis… (More)
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1984
Highly Cited
1984
Many intercalative antitumor drugs have been shown to cleave DNA indirectly through their specific effect on the stabilization of… (More)
Is this relevant?