tolvaptan

Known as: 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine, N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide 
An orally bioavailable, selective, arginine vasopressin receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia. Upon oral… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
BACKGROUND AND OBJECTIVES Autosomal dominant polycystic kidney disease (ADPKD), a frequent cause of end-stage renal disease, has… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Current management of autosomal dominant polycystic kidney disease (ADPKD) is focused on treating disease… (More)
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Highly Cited
2010
Highly Cited
2010
Vasopressin antagonists increase the serum sodium concentration in patients who have euvolemia and hypervolemia with hyponatremia… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND The postdischarge rehospitalization and death rates are high in patients with acute heart failure (HF) syndromes… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVES Our aim was to examine continental and regional differences in baseline characteristics and post-discharge clinical… (More)
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Highly Cited
2007
Highly Cited
2007
OBJECTIVES This study sought to examine the effects of vasopressin V2 receptor antagonism with tolvaptan on the changes in left… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Hospitalizations for worsening heart failure due to fluid overload (congestion) are common. Agents that treat… (More)
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Highly Cited
2004
Highly Cited
2004
CONTEXT Nearly 1 million hospitalizations for chronic heart failure occur yearly in the United States, with most related to… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND In this study, we evaluated the effects of tolvaptan (OPC-41061), a novel, oral, nonpeptide vasopressin V2-receptor… (More)
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