tolcapone

Known as: Tolcapon, Tolcapona, Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)- 
A benzophenone derivative and a catechol-O-methyltransferase (COMT) inhibitor. Tolcapone selectively and reversibly inhibits COMT, an enzyme that… (More)
National Institutes of Health

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Highly Cited
2007
Highly Cited
2007
Prefrontal cortical dopamine (DA) regulates various executive cognitive functions, including attention and working memory… (More)
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Highly Cited
2004
Highly Cited
2004
The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene affects activity of the enzyme and influences… (More)
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2003
2003
Tolcapone is a catechol-O-methyltransferase (COMT) inhibitor used for control of motor fluctuations in Parkinson's disease (PD… (More)
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2002
2002
Catechol-O-methyl transferase (COMT) inhibitors, entacapone and tolcapone, are used as an adjunctive treatment to L-dopa in… (More)
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2000
2000
The COMT inhibitors entacapone and tolcapone are rapidly metabolized in vivo, mainly by glucuronidation. In this work, the main… (More)
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Highly Cited
1999
Highly Cited
1999
The past year has seen several additions to the list of drugs that cause hepatic injury. Many of these agents produce fulminant… (More)
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1997
1997
In this double-blind, placebo-controlled trial, we investigated the effect of the catechol-O-methyltransferase inhibitor… (More)
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1997
1997
The aim of this study was to evaluate the effects of Tolcapone, a reversible, selective inhibitor of catechol-O-methyltransferase… (More)
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1994
1994
The potential antidepressant properties of tolcapone, a new catechol-O-methyl transferase (COMT) inhibitor, were investigated in… (More)
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