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tolcapone

Known as: Tolcapon, Tolcapona, Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)- 
A benzophenone derivative and a catechol-O-methyltransferase (COMT) inhibitor. Tolcapone selectively and reversibly inhibits COMT, an enzyme that… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Parkinson disease (PD) is the second most common neurodegenerative disorder after Alzheimer disease (AD). There is considerable… Expand
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Highly Cited
2009
Highly Cited
2009
The rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) tuberculosis around the world, including in… Expand
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Highly Cited
2007
Highly Cited
2007
Prefrontal cortical dopamine (DA) regulates various executive cognitive functions, including attention and working memory… Expand
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Highly Cited
2004
Highly Cited
2004
The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene affects activity of the enzyme and influences… Expand
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Review
1999
Review
1999
[Axelrod et al. (1958)][1] first described the enzyme-catalyzed O- methylation of catecholamines and other catechols in the late… Expand
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Highly Cited
1998
Highly Cited
1998
  • S. Fahn
  • Neurology
  • 1998
  • Corpus ID: 33129560
The articles in this supplement are based in part on the findings from a Special Session held during the 4th International… Expand
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Highly Cited
1998
Highly Cited
1998
developed raised aminotransferase (more than three times the upper limit of normal). Elevations were found between 6 and 12 weeks… Expand
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Highly Cited
1997
Highly Cited
1997
Tolcapone is a potent catechol-O-methyltransferase inhibitor that prolongs the plasma half-life of levodopa. This multicenter… Expand
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Highly Cited
1997
Highly Cited
1997
In this double-blind, placebo-controlled trial, we investigated the effect of the catechol-O-methyltransferase inhibitor… Expand
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Highly Cited
1997
Highly Cited
1997
We studied the new catechol-O-methyltransferase inhibitor tolcapone, 100 and 200 mg, three times daily (tid) in a randomized… Expand
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