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thymine biosynthetic process

Known as: thymine anabolism, thymine formation, thymine biosynthesis 
The chemical reactions and pathways resulting in the formation of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as… 
National Institutes of Health

Papers overview

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2015
2015
High-level QM/MM calculations support the concerted mechanism for Michael addition and covalent complex formation in thymidylate synthase.
Thymidylate synthase (TS) is a promising cancer target, due to its crucial function in thymine synthesis. It performs the… 
Highly Cited
2006
Highly Cited
2006
Studies on Fluorinated Pyrimidines XI . In Vitro Studies on Tumor Resistance
2001
2001
Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver.
Recently, we have reported that tegafur, an anticancer agent, is biotransformed into active drug 5-fluorouracil (5-FU) by… 
2000
2000
Structures of feline immunodeficiency virus dUTP pyrophosphatase and its nucleotide complexes in three crystal forms.
dUTP pyrophosphatase (dUTPase) cleaves the alpha-beta phosphodiester of dUTP to form pyrophosphate and dUMP, preventing… 
1973
1973
Defective DNA synthesis in human megaloblastic bone marrow: effects of hydroxy-B 12 5'-deoxyadenosyl-B 12 and methyl-B 12 .
In cobalamin deficiency, inadequate DNA-thymine synthesis appears to result from decreased conversion of N 5… 
1973
1973
Effect of Trimethoprim on Folate Metabolism in Human Bone Marrow
Summary: In vitro and in vivo effects of trimethoprim on folate metabolism have been studied in patients with normoblastic and… 
1972
1972
Response of DNA thymine synthesis in human tumor and normal tissue to 5-fluorouracil.
1957
1957
The mechanism of deoxyribonucleic acid-thymine biosynthesis by lymphatic tissues and tumors.
The conversion of formate-C14 or serine-3-C14 to DNA-thymine and free thymine, thymidine, and thymidylate was studied in vitro… 
Highly Cited
1956
Highly Cited
1956
Studies on the mode of action of azaserine.
Highly Cited
1954
Highly Cited
1954
THE INDUCTION OF THYMINE SYNTHESIS BY T2 INFECTION OF A THYMINE REQUIRING MUTANT OF ESCHERICHIA COLI
As a result of the discovery that T2, T4, and T6 bacteriophages contained a new pyrimidine, 5-hydroxymethyl cytosine, not present… 
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