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thymidylate synthase activity

Known as: methylenetetrahydrofolate:dUMP C-methyltransferase activity, 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity, dTMP synthase activity 
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. [EC:2.1.1.45, RHEA:12107]
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Dysregulated cellular proliferation is a characteristic property of cancer. We show that, despite this fact, cancers maintain… 
Highly Cited
1984
Highly Cited
1984
Isolated CF-1 mouse bone marrow cells were exposed for 1 hr to 5-fluorouracil (FUra) at concentrations from 1.8 to 50 microM and… 
Highly Cited
1981
Highly Cited
1981
The intracellular metabolism of a new fluoropyrimidine, 5'-deoxy-5-fluorouridine (5'-dFUrd), was compared with the metabolism of… 
Highly Cited
1980
Highly Cited
1980
This study describes the regulation of thymidylate synthetase activity in mouse 3T6 fibroblasts during serum-induced transitions… 
Highly Cited
1980
Highly Cited
1980
5'-Deoxy-5-fluorouridine (5'-dFUrd; Roche 21-9738) is a recently synthesized antineoplastic agent with therapeutic potential. The… 
Highly Cited
1980
Highly Cited
1980
L1210 mouse leukemia cells were synchronized by isoleucine deprivation followed by hydroxyurea treatment. Changes of thymidylate… 
Highly Cited
1978
Highly Cited
1978
Highly Cited
1970
Highly Cited
1970
Normal skin and actinic keratoses were exposed to fluorouracil in order to study its effect on deoxyribonucleic acid (DNA… 
Highly Cited
1966
Highly Cited
1966
Wilson, Melba Carr (Brown University, Providence, R.I.), James L. Farmer, and Frank Rothman. Thymidylate synthesis and…