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thymidylate synthase activity

Known as: methylenetetrahydrofolate:dUMP C-methyltransferase activity, 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity, dTMP synthase activity 
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. [EC:2.1.1.45, RHEA:12107]
National Institutes of Health

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Highly Cited
2006
Highly Cited
2006
Dysregulated cellular proliferation is a characteristic property of cancer. We show that, despite this fact, cancers maintain… Expand
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1993
1993
As a possible step to estimate the mechanism of the inhibitory role of Dunaliella bardawil (Db) in the initial progression of… Expand
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Highly Cited
1984
Highly Cited
1984
Isolated CF-1 mouse bone marrow cells were exposed for 1 hr to 5-fluorouracil (FUra) at concentrations from 1.8 to 50 microM and… Expand
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1981
1981
The intracellular metabolism of a new fluoropyrimidine, 5'-deoxy-5-fluorouridine (5'-dFUrd), was compared with the metabolism of… Expand
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Highly Cited
1980
Highly Cited
1980
This study describes the regulation of thymidylate synthetase activity in mouse 3T6 fibroblasts during serum-induced transitions… Expand
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Highly Cited
1980
Highly Cited
1980
5'-Deoxy-5-fluorouridine (5'-dFUrd; Roche 21-9738) is a recently synthesized antineoplastic agent with therapeutic potential. The… Expand
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1980
1980
L1210 mouse leukemia cells were synchronized by isoleucine deprivation followed by hydroxyurea treatment. Changes of thymidylate… Expand
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Highly Cited
1978
Highly Cited
1978
Abstract A 5-fluorocytosine-sensitive isolate of Candida albicans was examined for the presence of thymidylate synthetase… Expand
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1977
1977
Thymidylate synthetase activity was measured in crude extracts of the yeast Saccharomyces cerevisiae by a sensitive radiochemical… Expand
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Highly Cited
1970
Highly Cited
1970
Normal skin and actinic keratoses were exposed to fluorouracil in order to study its effect on deoxyribonucleic acid (DNA… Expand
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