thymidylate synthase activity
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Dysregulated cellular proliferation is a characteristic property of cancer. We show that, despite this fact, cancers maintain… Expand Isolated CF-1 mouse bone marrow cells were exposed for 1 hr to 5-fluorouracil (FUra) at concentrations from 1.8 to 50 microM and… Expand The intracellular metabolism of a new fluoropyrimidine, 5'-deoxy-5-fluorouridine (5'-dFUrd), was compared with the metabolism of… Expand This study describes the regulation of thymidylate synthetase activity in mouse 3T6 fibroblasts during serum-induced transitions… Expand 5'-Deoxy-5-fluorouridine (5'-dFUrd; Roche 21-9738) is a recently synthesized antineoplastic agent with therapeutic potential. The… Expand L1210 mouse leukemia cells were synchronized by isoleucine deprivation followed by hydroxyurea treatment. Changes of thymidylate… Expand Abstract A 5-fluorocytosine-sensitive isolate of Candida albicans was examined for the presence of thymidylate synthetase… Expand Normal skin and actinic keratoses were exposed to fluorouracil in order to study its effect on deoxyribonucleic acid (DNA… Expand Abstract The tritium atom of deoxyuridylate-5-3H is obligatorily displaced in the thymidylate synthetase reaction and… Expand Wilson, Melba Carr (Brown University, Providence, R.I.), James L. Farmer, and Frank Rothman. Thymidylate synthesis and… Expand