thymidylate synthase activity

Known as: methylenetetrahydrofolate:dUMP C-methyltransferase activity, 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity, dTMP synthase activity 
Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. [EC:2.1.1.45, RHEA:12107]
National Institutes of Health

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2006
2006
Dysregulated cellular proliferation is a characteristic property of cancer. We show that, despite this fact, cancers maintain… (More)
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1984
1984
Isolated CF-1 mouse bone marrow cells were exposed for 1 hr to 5-fluorouracil (FUra) at concentrations from 1.8 to 50 microM and… (More)
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1983
1983
Two agents, 3-aminobenzamide (3-AB) and beta lapachone, that inhibit repair of mammalian cell DNA damaged by methyl methane… (More)
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1981
1981
The intracellular metabolism of a new fluoropyrimidine, 5'-deoxy-5-fluorouridine (5'-dFUrd), was compared with the metabolism of… (More)
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Highly Cited
1980
Highly Cited
1980
This study describes the regulation of thymidylate synthetase activity in mouse 3T6 fibroblasts during serum-induced transitions… (More)
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1980
1980
5'-Deoxy-5-fluorouridine (5'-dFUrd; Roche 21-9738) is a recently synthesized antineoplastic agent with therapeutic potential. The… (More)
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1977
1977
Thymidylate synthetase activity was measured in crude extracts of the yeast Saccharomyces cerevisiae by a sensitive radiochemical… (More)
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1972
1972
Changes in thymidylate synthetase specific activity in Don Chinese hamster cells grown in vitro have been examined during the… (More)
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1969
1969
Infection of a thymineless strain of Bacillus subtilis with cither the temperate phage 43 or its clear plaque mutant ~3c enabled… (More)
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