FAQ

thymidylate kinase activity

Known as: thymidylate monophosphate kinase activity, thymidine monophosphate kinase activity, thymidine 5'-monophosphate kinase activity 
Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. [EC:2.7.4.9]

Topic mentions per year

Topic mentions per year

1960-2010
02419602010

Papers overview

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2003
2003
Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Crystal structures of equine herpesvirus type-4 thymidine kinase (EHV4-TK) in complex with (i). thymidine and ADP, (ii… (More)
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2003
2003
Two different thymidylate kinase gene homologues, including one that has catalytic activity, are encoded in the onion yellows phytoplasma genome.
Thymidylate kinase (TMK) catalyses the phosphorylation of dTMP to form dTDP in both the de novo and salvage pathways of dTTP… (More)
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2000
2000
Conservative mutations of glutamine-125 in herpes simplex virus type 1 thymidine kinase result in a ganciclovir kinase with minimal deoxypyrimidine kinase activities.
The herpes simplex virus type 1 thymidine kinase (HSV-1 TK) is the major anti-herpes virus pharmacological target, and it is… (More)
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1998
1998
The Epstein-Barr virus thymidine kinase does not phosphorylate ganciclovir or acyclovir and demonstrates a narrow substrate specificity compared to the herpes simplex virus type 1 thymidine kinase.
The Epstein-Barr virus (EBV) thymidine kinase (TK) was expressed in mammalian 143B TK- cells to investigate its substrate… (More)
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1998
1998
Decrease in thymidylate kinase activity in peripheral blood mononuclear cells from HIV-infected individuals.
Nucleosides and nucleoside analogs are anabolised to their triphosphates by intracellular kinases. The anti-HIV analogue… (More)
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1985
1985
HSV1-specific thymidylate kinase activity in infected cells.
Several 5-methoxymethyldeoxyuridine (MMdU)-resistant mutants of herpes simplex virus type 1 (HSV1) were classified by measuring… (More)
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1984
1984
Yeast gene CDC8 encodes thymidylate kinase and is complemented by herpes thymidine kinase gene TK.
The herpes simplex virus type 1 thymidine kinase gene TK complements the defect in five temperature-sensitive mutants and in… (More)
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1984
1984
The CDC8 gene of yeast encodes thymidylate kinase.
Thymidylate kinase catalyzes the phosphorylation of thymidine 5'-monophosphate to thymidine 5'-diphosphate in the pathway of… (More)
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1979
1979
Characterization of pyrimidine deoxyribonucleoside kinase (thymidine kinase) and thymidylate kinase as a multifunctional enzyme in cells transformed by herpes simplex virus type 1 and in cells…
Pyrimidine deoxyribonucleoside kinase (thymidine kinase [TK]) was purified from two herpes simplex virus type 1 (HVS-1… (More)
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1978
1978
Association of thymidylate kinase activity with pyrimidine deoxyribonucleoside kinase induced by herpes simplex virus.
Thymidine kinase derived from LMTK+ does not exhibit thymidylate kinase activity. However, protein isolated by affinity column… (More)
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