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thymidylate kinase activity

Known as: thymidylate monophosphate kinase activity, thymidine monophosphate kinase activity, thymidine 5'-monophosphate kinase activity 
Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. [EC:2.7.4.9]
National Institutes of Health

Papers overview

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2003
2003
Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
Crystal structures of equine herpesvirus type-4 thymidine kinase (EHV4-TK) in complex with (i). thymidine and ADP, (ii… Expand
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2001
2001
Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.
The broad substrate specificity of herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) has provided the basis for selective… Expand
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1998
1998
The Epstein-Barr virus thymidine kinase does not phosphorylate ganciclovir or acyclovir and demonstrates a narrow substrate specificity compared to the herpes simplex virus type 1 thymidine kinase.
The Epstein-Barr virus (EBV) thymidine kinase (TK) was expressed in mammalian 143B TK- cells to investigate its substrate… Expand
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1998
1998
Decrease in thymidylate kinase activity in peripheral blood mononuclear cells from HIV-infected individuals.
Nucleosides and nucleoside analogs are anabolised to their triphosphates by intracellular kinases. The anti-HIV analogue… Expand
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1984
1984
The CDC8 gene of yeast encodes thymidylate kinase.
Thymidylate kinase catalyzes the phosphorylation of thymidine 5'-monophosphate to thymidine 5'-diphosphate in the pathway of… Expand
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1979
1979
Characterization of pyrimidine deoxyribonucleoside kinase (thymidine kinase) and thymidylate kinase as a multifunctional enzyme in cells transformed by herpes simplex virus type 1 and in cells…
Pyrimidine deoxyribonucleoside kinase (thymidine kinase [TK]) was purified from two herpes simplex virus type 1 (HVS-1… Expand
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1978
1978
Association of thymidylate kinase activity with pyrimidine deoxyribonucleoside kinase induced by herpes simplex virus.
Thymidine kinase derived from LMTK+ does not exhibit thymidylate kinase activity. However, protein isolated by affinity column… Expand
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1965
1965
The synergistic anti-neoplastic activity of combinations of mitomycins with either 6-thioguanine or 5-fluorouracil.
Summary Mitomycin C or porfiromycin (methyl mitomycin) in combination with either 6-thioguanine or 5-fluorouracil produced… Expand
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1964
1964
METABOLIC ALTERATIONS AFTER TOTAL BODY DOSES OF X-RADIATION. EFFECT OF IRRADIATION OF NORMAL LIVER ON DNA SYNTHESIS AFTER PARTIAL HEPATECTOMY.
Abstract DNA and RNA synthesis in regenerating rat liver were investigated in vivo and in vitro in animals irradiated prior to… Expand
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1964
1964
Studies on thymidylate phosphatase, thymidine kinase and thymidylate kinase activities in some transplantable rat hepatomas.
Summary Thymidylate phosphatase distribution and specific activity was measured in a series of transplantable hepatomas, the host… Expand
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