therapeutic index

Known as: Therapeutic Ratio, Therapeutic Window, index therapeutic 
The difference between the concentration at which clinical benefit is seen and that at which toxicity occurs. It is expressed as the range between… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Liposomes are the first nano drug delivery systems that have been successfully translated into real-time clinical applications… (More)
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Review
2012
Review
2012
A key part of drug discovery and development is the characterization and optimization of the safety and efficacy of drug… (More)
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Review
2011
Review
2011
Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE Despite their preclinical promise, previous MEK inhibitors have shown little benefit for patients. This likely reflects… (More)
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Highly Cited
2004
Highly Cited
2004
Loss of integrity of the blood-brain barrier (BBB) resulting from ischemia/reperfusion is believed to be a precursor to… (More)
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Review
2001
Review
2001
  • International journal of radiation oncology…
  • 2001
PURPOSE To develop and disseminate a report aimed primarily at practicing radiation oncology physicians and medical physicists… (More)
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Highly Cited
1999
Highly Cited
1999
The only treatment of patients with acute ischemic stroke is thrombolytic therapy, which benefits only a fraction of stroke… (More)
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Highly Cited
1998
Highly Cited
1998
Programmed cell death (apoptosis) is a normal process in the developing nervous system. Recent data suggest that certain features… (More)
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Highly Cited
1992
Highly Cited
1992
Falls in gastric intramucosal pH (pHi) are associated with morbidity and mortality in patients admitted to intensive-care units… (More)
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Highly Cited
1992
Highly Cited
1992
We have investigated the tissue distribution, toxicity, and antitumor activity of anthracyclines encapsulated in hydrogenated… (More)
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