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therapeutic index

Known as: Therapeutic Ratio, Therapeutic Window, index therapeutic 
The difference between the concentration at which clinical benefit is seen and that at which toxicity occurs. It is expressed as the range between… 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

drug potency

Papers overview

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Review
2009
Review
2009
Factor Xa inhibitors
Summary Oral factor Xa (FXa) inhibitors are a promising alternative to current anticoagulants. This paper reviews the latest… 
Review
1999
Review
1999
Evaluation of fractionation regimens in stereotactic radiotherapy using a mathematical model of repopulation and reoxygenation.
PURPOSE Various forms of stereotactic fractionation regimens have been used in the clinic. The purpose of this article is to… 
Review
1996
Review
1996
Pharmacokinetic Individualisation of Zidovudine Therapy
SummaryZidovudine is the cornerstone of current antiretroviral treatment of human immunodeficiency virus (HIV) infection. Its use… 
1991
1991
Metabolism of ethanol and associated hepatotoxicity.
Over the last three decades, direct hepatotoxic effects of ethanol were established, some of which were linked to redox changes… 
1982
1982
Effect of pyrimidines, purines and their nucleosides on antitumor activity of 5-fluorouracil against L-1210 leukemia.
The chemotherapeutic action of 5-fluorouracil (5-FU) monotherapy on L-1210 leukemia in mice was compared with combinations of… 
1980
1980
Radiation therapy for advanced head and neck squamous-cell carcinoma using twice-a-day fractionation.
Fifteen patients with massive advanced squamous-cell carcioma of the head and neck received radiation therapy under the twice-a… 
1980
1980
Clinical significance of radiation therapy combined with chemotherapy.
With the aim of reducing the side-effects in the surrounding healthy tissues, and/or improving the local control rate… 
Highly Cited
1980
Highly Cited
1980
Vinblastine given as a continuous 5-day infusion in the treatment of refractory advanced breast cancer.
In an attempt to improve the therapeutic index of vinblastine by maintaining a prolonged, constant plasma level, it was given as… 
1979
1979
Biologic activity of MCNU: a new antitumor agent.
A novel nitrosourea derivative, methyl-6-[[[(2-chloroethyl)nitrosoamino]carbonyl]-amino]-6-deoxy-alpha-D-glucopyranoside (MCNU… 
1975
1975
A low dose-fractionation shceme for the radiotherapy of carcinoma of the bladder. Experimental background and preliminary results.
Experimental observations are described which form the basis of a low dose-fractionation scheme designed in an attempt to…