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tetrahydropyrimidinone

National Institutes of Health

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Pyrimidinones

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2020
2020
In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis
Background and Purpose Tuberculosis has been reported to be the worldwide leading cause of death resulting from a sole infectious… Expand
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2020
2020
A novel one-pot method for the stereoselective synthesis of tetrahydropyrimidinones in a low melting mixture.
A direct and metal free one-pot method has been developed for the stereoselective synthesis of tetrahydropyrimidinone derivatives… Expand
2014
2014
Novel estrogen receptor (ER) modulators containing various hydrophobic bent-core structures.
We previously discovered m-carborane-containing estrogen receptor (ER) modulator 4, which exhibits weak ER-agonistic and… Expand
2014
2014
SYNTHESIS OF DE NOVO CHIRAL γ-AMINO-YNAMIDES USING LITHIATED YNAMIDES. OBSERVATION OF A UNIQUE 5-ENDO-DIG CYCLIZATION WITH AN INVERSION OF S-CENTER.
We describe herein details of our efforts in developing a highly stereoselective synthesis of de novo chiral γ-amino-ynamides… Expand
2011
2011
Synthesis and Evaluation of Metabotropic Glutamate Receptor Subtype 5 Antagonists Based on Fenobam().
In an effort to discover potent and selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonists, 15… Expand
2011
2011
Novel asparagine-derived lipid enhances distearoylphosphatidylcholine bilayer resistance to acidic conditions.
A novel asparagine-derived lipid analogue (ALA(11,17)) bearing a tetrahydropyrimidinone headgroup and two fatty chains (11 and 17… Expand
2009
2009
A novel multicomponent synthesis of polyfunctionalized bicyclic tetrahydropyrimidinone derivatives via mercaptoacetylative ring transformations.
A novel K-10 clay (nanoclay)-catalyzed expeditious synthesis of polyfunctionalized bicyclic pyrimidines using unprotected aldoses… Expand
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2005
2005
Using microwave irradiation to prepare new poly(amide-imide)s containing tetrahydropyrimidinone, tetrahydro-2-thioxopyrimidine, and trimellitic rings in their main chains: Synthesis and…
Under irradiation in a microwave oven, six novel poly(amide-imide)s containing tetrahydropyrimidinone, tetrahydro-2… Expand
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2005
2005
Hydrophobicity in the design of P2/P2' tetrahydropyrimidinone HIV protease inhibitors.
As part of an ongoing effort in understanding the role of hydrophobicity in the design of nonpeptidic HIV protease inhibitors… Expand
2001
2001
Mild Pd(OAc)2/PPh3 Catalyzed Cyclization Reactions of 2-Vinylazetidines with Heterocumulenes: An Atom-Economy Synthesis of Tetrahydropyrimidinone, Tetrahydropyrimidinimine, and Thiazinanimine Analogs
A versatile method for the reaction of N-alkyl-2-vinylazetidines with heterocumulenes has been established using a Pd(OAc)2/PPh3… Expand
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