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tetrahydrofolate biosynthetic process

Known as: tetrahydrofolate synthesis, tetrahydrofolate biosynthesis, tetrahydrofolate formation 
The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing… 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities
Genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) have consistently observed strong evidence of… 
Review
2007
Review
2007
Nutrigenetics and nutraceuticals: the next wave riding on personalized medicine.
  • M. Subbiah
  • Translational research : the journal of…
  • 2007
  • Corpus ID: 45698775
Highly Cited
2006
Highly Cited
2006
Discovery of a New Prokaryotic Type I GTP Cyclohydrolase Family*
GTP cyclohydrolase I (GCYH-I) is the first enzyme of the de novo tetrahydrofolate biosynthetic pathway present in bacteria, fungi… 
Highly Cited
2004
Highly Cited
2004
Abyssomicin C-A polycyclic antibiotic from a marine Verrucosispora strain as an inhibitor of the p-aminobenzoic acid/tetrahydrofolate biosynthesis pathway.
Highly Cited
2003
Highly Cited
2003
One-Carbon Metabolism in Plants. Regulation of Tetrahydrofolate Synthesis during Germination and Seedling Development
Tetrahydrofolate (THF) is a central cofactor for one-carbon transfer reactions in all living organisms. In this study, we… 
Highly Cited
2002
Highly Cited
2002
Folate synthesis in higher-plant mitochondria: coupling between the dihydropterin pyrophosphokinase and the dihydropteroate synthase activities.
The plant enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/7,8-dihydropteroate synthase (HPPK/DHPS) is a mitochondrial… 
Highly Cited
1993
Highly Cited
1993
Corrinoid-Dependent Methyl Transfer Reactions Are Involved in Methanol and 3,4-Dimethoxybenzoate Metabolism by Sporomusa ovata
Washed and air-oxidized proteins from Sporomusa ovata cleaved the C-O bond of methanol or methoxyaromatics and transferred the… 
Review
1977
Review
1977
Folate metabolism in malaria.
  • R. Ferone
  • Bulletin of the World Health Organization
  • 1977
  • Corpus ID: 21085700
It is known that malaria parasites are inhibited by sulfonamides and antifolate compounds, require 4-aminobenzoic acid for growth… 
1976
1976
Exchangeable intracellular methotrexate levels in the presence and absence of vincristine at extracellular drug concentrations relevant to those achieved in high-dose methotrexate-folinic acid…
Studies were undertaken to (a) assess intracellular methotrexate (MTX) levels at extracellular drug concentrations comparable to… 
1974
1974
Folic acid non-dependent formiminoglutamic aciduria in two siblings.
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