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tenapanor

 
National Institutes of Health

Papers overview

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2019
2019
Abstract Background Elevated serum fibroblast growth factor 23 (FGF23) is strongly associated with cardiovascular risk and… Expand
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2018
2018
Tenapanor inhibits sodium/hydrogen exchanger isoform 3 to reduce intestinal phosphate absorption via reduction of passive… Expand
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2018
2018
By the combined use of powder and single-crystal X-ray diffraction, solid-state NMR, and molecular modeling, the crystal… Expand
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2018
2018
BackgroundTenapanor, a small molecule with minimal systemic availability, is a first-in-class sodium/hydrogen exchanger 3 (NHE3… Expand
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2017
2017
Hyperphosphatemia is common among patients with CKD stage 5D and is associated with morbidity and mortality. Current guidelines… Expand
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2017
2017
Objectives:Tenapanor is a first-in-class, small-molecule inhibitor of the gastrointestinal sodium/hydrogen exchanger NHE3. This… Expand
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2016
2016
BackgroundTenapanor (RDX5791, AZD1722), a small molecule with minimal systemic availability, is an inhibitor of the sodium… Expand
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2016
2016
BACKGROUND AND OBJECTIVES Interdialytic weight gain in patients on hemodialysis is associated with adverse cardiovascular… Expand
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Highly Cited
2015
Highly Cited
2015
In CKD, phosphate retention arising from diminished GFR is a key early step in a pathologic cascade leading to hyperthyroidism… Expand
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Highly Cited
2014
Highly Cited
2014
An inhibitor of intestinal NHE3 reduces absorption of dietary sodium in rats and humans and prevents salt-induced cardiorenal… Expand
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