temelastine

Because previous studies suggest an antinociceptive role for the neuromodulator histamine (HA) in the periaqueductal grey or the… (More)

A species comparison of the metabolic pathways of temelastine has been made using hepatocyte preparations from rat, dog… (More)

The toxicity of temelastine 2-[4-(5-bromo-3-methylpyrid-2-yl)butylamino]-5-[(6-methylpyrid+ ++-3-yl) methyl]-4-pyrimidone a… (More)

Temelastine (SK&F 93944), an H1 histamine receptor antagonist, induces thyroid histopathological lesions in the rat, indicative… (More)

Competition by the potent selective H1-receptor antagonist temelastine (SK & F 93944) with [3H]mepyramine binding to mouse cortex… (More)

The pharmacokinetics of theophylline (i.v. aminophylline 250 mg) were studied in a balanced, double-blind crossover following the… (More)

Thirteen healthy subjects participated in a combined acute and subacute double-blind, crossover trial of two H1-antihistamines… (More)

SK&F 93944 (temelastine), a novel histamine H1-receptor antagonist, has been studied in a variety of in vitro and in vivo test… (More)

Temelastine is a selective, competitive histamine H1-receptor antagonist which does not penetrate the central nervous system. The… (More)

SK&F 93944, a previously reported non-sedating histamine H1-receptor antagonist, was evaluated for its ability to block… (More)