telomerase activity

Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1998
Highly Cited
1998
Normal somatic cells have a finite life span [1] and lose telomeric DNA, present at the ends of chromosomes, each time they… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Catalytic protein subunits of telomerase from the ciliate Euplotes aediculatus and the yeast Saccharomyces cerevisiae contain… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Telomerase is a ribonucleoprotein that synthesizes telomere repeats onto chromosome ends and is involved in maintaining telomere… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Immortalization of human cells is often associated with reactivation of telomerase, a ribonucleoprotein enzyme that adds TTAGGG… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Eukaryotic chromosomes are capped with repetitive telomere sequences that protect the ends from damage and rearrangements… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Bone marrow and peripheral blood leukocytes from 19 leukemia patients were found to contain telomerase activity detectable by a… (More)
  • figure 1
  • figure 2
  • table 1
  • table 2
  • figure 3
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Although many genetic alterations have been reported in gastric cancer, it is not known whether all gastric tumors are capable of… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Telomerase activity was analysed in 100 neuroblastoma cases. Although telomerase activity was not detected in normal adrenal… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Synthesis of DNA at chromosome ends by telomerase may be necessary for indefinite proliferation of human cells. A highly… (More)
Is this relevant?
Highly Cited
1992
Highly Cited
1992
Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication… (More)
  • table I
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?