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telomerase activity

Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one… 
National Institutes of Health

Related topics

Related topics

4 relations
regulation of telomerase activitytelomerase inhibitor activity

Broader (1)

telomere maintenance via telomerase

Narrower (1)

template for synthesis of G-rich strand of telomere DNA activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Advances in the detection of telomerase activity using isothermal amplification
Telomerase plays a significantly important role in keeping the telomere length of a chromosome. Telomerase overexpresses in… 
Highly Cited
2010
Highly Cited
2010
Fluorescence detection of telomerase activity in cancer cells based on isothermal circular strand-displacement polymerization reaction.
On the basis of the extension reaction of a telomerase substrate (TS) primer in the presence of the telomerase, the inherent… 
Highly Cited
2001
Highly Cited
2001
Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase.
Telomerase activity is necessary and sufficient for immortality in many cells and hence represents a prime target for antitumor… 
Highly Cited
2000
Highly Cited
2000
Interferon alpha down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells.
Recently, the derepressed expression of the catalytic subunit of telomerase, human telomerase reverse transcriptase (hTERT), the… 
Highly Cited
1998
Highly Cited
1998
Telomerase activity and telomere length in pediatric patients with malignancies undergoing chemotherapy
Telomerase activity and telomere length in mononuclear cells (MNCs) and granulocytes from peripheral blood (PB) and bone marrow… 
Highly Cited
1997
Highly Cited
1997
Telomerase activity is associated with cell cycle deregulation in human breast cancer.
Deregulation of the cell cycle by abnormal expression of one or several cell cycle regulatory proteins is a common finding in… 
Highly Cited
1996
Highly Cited
1996
Detection of telomerase activity in oral rinses from head and neck squamous cell carcinoma patients.
Telomerase is a ribonucleoprotein that maintains telomere length and whose activity is associated with escape from cellular… 
Highly Cited
1996
Highly Cited
1996
Telomerase activity is induced by the stimulation to antigen receptor in human peripheral lymphocytes.
Impairment of replicating DNA ends by normal DNA polymerases and the gradual shrink of the ends of linear chromosomes (telomeres… 
Highly Cited
1995
Highly Cited
1995
Increased telomerase activity in mouse skin premalignant progression.
It has been postulated that the expression of the ribonucleoprotein telomerase is necessary to overcome cellular senescence and… 
Highly Cited
1994
Highly Cited
1994
Functional reconstitution of wild-type and mutant Tetrahymena telomerase.
Telomerase is a ribonucleoprotein that catalyzes telomere elongation in vitro and in vivo. The 159-nucleotide RNA component of… 
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