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taxane 13-alpha-hydroxylase activity

Known as: taxa-4(20),11-dien-5alpha-ol,NADPH:oxygen oxidoreductase (13alpha-hydroxylating), taxane 13a-hydroxylase activity, taxane 13alpha-hydroxylase activity 
Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-ol = H(2)O + NADP(+) + taxa-4(20),11-dien-5alpha,13alpha-diol. [EC:1.14.13… Expand
National Institutes of Health

Papers overview

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2019
2019
Introduction Epithelial ovarian carcinoma (EOC) is one of the most lethal gynecologic malignancies, with a poor 5-year survival… Expand
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Review
2016
Review
2016
Background. H+BC is an aggressive variant of BC with earlier and more frequent metastatic relapse than HER2 normal disease… Expand
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Review
2014
Review
2014
Prostate cancer is the most common malignancy in Western Europe, of which approximately 10-20% presents with advanced or… Expand
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2013
2013
Background: Recurrence rates have declined since AT was added to chemotherapy (chx) for her2+ early breast cancer (BC). This has… Expand
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Review
2011
Review
2011
Castration-resistant prostate cancer (CRPC) has a poor prognosis and remains a significant therapeutic challenge. Before 2010… Expand
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2011
2011
1030 Background: The adjuvant chemotherapy +/- endocrine survival (ACES) predictor is a microarray-based genomic algorithm that… Expand
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2003
2003
Two new taxane diterpenoids, tasumatrols A (1) and B (2), have been isolated from extracts of the leaves and twigs of Taiwanese… Expand
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2002
2002
Two new taxane diterpenes, dantaxusin C (1) and dantaxusin D (2), were isolated from an ethanol extract of the aerial parts of… Expand
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