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taxane 13-alpha-hydroxylase activity

Known as: taxa-4(20),11-dien-5alpha-ol,NADPH:oxygen oxidoreductase (13alpha-hydroxylating), taxane 13a-hydroxylase activity, taxane 13alpha-hydroxylase activity 
Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-ol = H(2)O + NADP(+) + taxa-4(20),11-dien-5alpha,13alpha-diol. [EC:1.14.13… Expand
National Institutes of Health

Papers overview

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2019
2019
MicroRNA-331-3p inhibits proliferation and metastasis of ovarian cancer by targeting RCC2
Introduction Epithelial ovarian carcinoma (EOC) is one of the most lethal gynecologic malignancies, with a poor 5-year survival… Expand
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Review
2016
Review
2016
Abstract P4-12-01: Long term follow up of patients (pts) with HER2positive (H+) early stage breast cancer (ESBC) treated with trastuzumab (T)
Background. H+BC is an aggressive variant of BC with earlier and more frequent metastatic relapse than HER2 normal disease… Expand
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Review
2014
Review
2014
Molecular alterations and emerging targets in castration resistant prostate cancer.
Prostate cancer is the most common malignancy in Western Europe, of which approximately 10-20% presents with advanced or… Expand
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2013
2013
Abstract P2-15-01: Impact of adjuvant trastuzumab (AT) on survival in metastatic (M1) her2 positive breast cancer
Background: Recurrence rates have declined since AT was added to chemotherapy (chx) for her2+ early breast cancer (BC). This has… Expand
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Review
2011
Review
2011
The changing therapeutic landscape of castration-resistant prostate cancer
Castration-resistant prostate cancer (CRPC) has a poor prognosis and remains a significant therapeutic challenge. Before 2010… Expand
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2011
2011
Blinded validation study of genomic predictions for survival following adjuvant sequential anthracycline-docetaxel chemotherapy with or without endocrine therapy.
1030 Background: The adjuvant chemotherapy +/- endocrine survival (ACES) predictor is a microarray-based genomic algorithm that… Expand
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2007
2007
SS8-5 ホルモン抵抗性再燃前立腺癌 (HRPC) に対する Taxane 系抗癌剤、Estramustine、Carboplatin 併用化学療法 (TEC療法)(前立腺再燃癌の機序, 第95回日本泌尿器科学会総会)
 
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2003
2003
New taxane diterpenoids from Taiwanese Taxus sumatrana.
Two new taxane diterpenoids, tasumatrols A (1) and B (2), have been isolated from extracts of the leaves and twigs of Taiwanese… Expand
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2002
2002
Dantaxusins C and D, two novel taxoids from Taxus yunnanensis.
Two new taxane diterpenes, dantaxusin C (1) and dantaxusin D (2), were isolated from an ethanol extract of the aerial parts of… Expand
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