FAQ

t(4;11)

A cytogenetic abnormality that involves a translocation between chromosomes 4 and 11.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2017
0102019752017

Related topics

Related topics

2 relations
Chromosomes, Human, Pair 11Chromosomes, Human, Pair 4

Related mentions per year

Related mentions per year

1955-2018
1960198020002020
t(4;11)
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 4

Papers overview

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2010
2010
DNA copy-number abnormalities do not occur in infant ALL with t(4;11)/MLL-AF4
The pathogenesis of infant acute lymphoblastic leukemia (ALL) is still not well defined. Short latency to leukemia and very high… (More)
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Highly Cited
2009
Highly Cited
2009
HOXA9 is required for survival in human MLL-rearranged acute leukemias.
Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique biologic characteristics and… (More)
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Highly Cited
1999
Highly Cited
1999
Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia.
To define prognostic factors in infant acute lymphoblastic leukemia (ALL), the outcome of 106 infants (age </=12 months) during 3… (More)
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Highly Cited
1999
Highly Cited
1999
Prospective karyotype analysis in adult acute lymphoblastic leukemia: the cancer and leukemia Group B experience.
The Cancer and Leukemia Group B (CALGB) has been conducting a prospective cytogenetic companion study (CALGB 8461) to all CALGB… (More)
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1996
1996
LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias.
A novel human gene, LAF-4, was isolated from a subtracted cDNA library that showed strong sequence similarity to AF-4, a gene… (More)
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1993
1993
A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias.
Translocations involving chromosome band 11q23 in acute leukemias have recently been shown to involve the HRX gene that codes for… (More)
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Highly Cited
1992
Highly Cited
1992
The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene.
The ALL-1 gene located at human chromosome 11 band q23 is rearranged in acute leukemias with interstitial deletions or reciprocal… (More)
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Highly Cited
1991
Highly Cited
1991
Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): a collaborative study of 40 cases.
The t(4;11)(q21;q23) chromosomal abnormality was identified in 40 (2%) of 1,986 children with newly diagnosed acute lymphoblastic… (More)
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1991
1991
Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations.
Chromosomal region 11q23 participates in a number of reciprocal translocations with specific regions of chromosomes 4, 9, 19, and… (More)
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Highly Cited
1985
Highly Cited
1985
Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics.
A cell line, designated RS4;11, was established from the bone marrow of a patient in relapse with an acute leukemia that was… (More)
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