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sunitinib malate

Known as: 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide), Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1) 
The orally bioavailable malate salt of an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
BACKGROUND The multitargeted tyrosine kinase inhibitor sunitinib has shown activity against pancreatic neuroendocrine tumors in… Expand
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Highly Cited
2010
Highly Cited
2010
The standard of care for managing patients with gastrointestinal stromal tumors (GISTs) rapidly changed after the introduction of… Expand
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Highly Cited
2009
Highly Cited
2009
AIMS To assess the antitumour activity, safety, pharmacokinetics and pharmacodynamics of continuous daily sunitinib dosing in… Expand
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Highly Cited
2008
Highly Cited
2008
PURPOSE Sunitinib is an oral, multitargeted tyrosine kinase inhibitor that inhibits vascular endothelial growth factor receptor… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Since sunitinib malate has shown activity in two uncontrolled studies in patients with metastatic renal-cell carcinoma… Expand
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Highly Cited
2007
Highly Cited
2007
Cancer patients treated with antiangiogenic multitargeted receptor tyrosine kinase (RTK) inhibitors show increased levels of… Expand
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Review
2007
Review
2007
Sunitinib malate (SU11248/Sutent; Pfizer) is a multitargeted tyrosine kinase inhibitor that has potent anti-angiogenic and… Expand
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Highly Cited
2006
Highly Cited
2006
Context Current treatment options for metastatic renal cell carcinoma (RCC) are limited and there is a need to identify novel and… Expand
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Highly Cited
2006
Highly Cited
2006
CONTEXT Current treatment options for metastatic renal cell carcinoma (RCC) are limited and there is a need to identify novel and… Expand
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Highly Cited
2006
Highly Cited
2006
PURPOSE Renal cell carcinoma (RCC) is characterized by loss of von Hippel Lindau tumor suppressor gene activity, resulting in… Expand
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