sulofenur

Known as: 1H-Indene-5-sulfonamide, N-(((4-chlorophenyl)amino)carbonyl)-2,3-dihydro-, ISCU, N-(5-indanylsulfonyl)-N'-(4-chlorophenyl)urea 
A diarylsulfonylurea with potential antineoplastic activity. Sulofenur's antineoplastic mechanism of action is unknown. (NCI04)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2018
051019892018

Papers overview

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2013
2013
Background:Clear cell renal cancer frequently harbours von Hippel–Lindau (VHL) gene mutations, leading to stabilisation of the… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Frataxin, the mitochondrial protein deficient in Friedreich ataxia, a rare autosomal recessive neurodegenerative… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1) and a microRNA, hsa-miR-210 (miR… (More)
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2009
2009
Myopathy with deficiency of succinate dehydrogenase and aconitase is a recessively inherited disorder characterized by childhood… (More)
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Highly Cited
2008
Highly Cited
2008
A myopathy with severe exercise intolerance and myoglobinuria has been described in patients from northern Sweden, with… (More)
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2006
Highly Cited
2006
Iron-sulfur (Fe-S) clusters are required for the functions of mitochondrial aconitase, mammalian iron regulatory protein 1, and… (More)
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2006
2006
Iron-sulfur clusters are prosthetic groups composed of sulfur and iron that are found in respiratory chain complexes and numerous… (More)
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Highly Cited
2001
Highly Cited
2001
The cysteine desulfurase enzymes NifS and IscS provide sulfur for the biosynthesis of Fe/S proteins. NifU and IscU have been… (More)
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Highly Cited
2000
Highly Cited
2000
Iron-sulfur cluster biosynthesis in both prokaryotic and eukaryotic cells is known to be mediated by two highly conserved… (More)
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1991
1991
The elimination and metabolism of sulofenur [N-(5-indanesulfonyl)-N'-(4-chlorophenyl)urea, LY186641] was examined in mice, rats… (More)
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