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sulindac sulfone

Known as: (Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic Acid, Exisulind 
An inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. After oral administration, sulindac undergoes extensive… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (4)

Anticarcinogenic AgentsAntineoplastic AgentsCyclooxygenase InhibitorsSulindac

Narrower (3)

AptosynCP248FGN-1
analogs & derivativescarboplatin/exisulind/gemcitabine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Phase II Evaluation of Docetaxel Plus Exisulind in Patients With Androgen Independent Prostate Carcinoma
Objectives:In this phase II study, the combination of docetaxel and exisulind (a GMP phosphodiesterase inhibitor) was given to… 
2006
2006
Capillary electrophoresis combining field-amplified sample stacking and electroosmotic flow suppressant for analysis of sulindac and its two metabolites in plasma.
2005
2005
A phase I/II dose‐escalation study of exisulind and docetaxel in patients with hormone‐refractory prostate cancer
To determine the safety and efficacy, in a dose‐escalation study, of exisulind (an oral sulphone metabolite of sulindac thought… 
2005
2005
Sulindac Sulfone Is Most Effective in Modulating β‐Catenin‐Mediated Transcription in Cells with Mutant APC
Abstract: Sulindac sulfone (FGN‐1, Aptosyn), a metabolite of the nonsteroidal anti‐inflammatory drug sulindac, lacks… 
2004
2004
Suppression of angiogenic activity of sera from diabetic patients with non-proliferative retinopathy by compounds of herbal origin and sulindac sulfone.
Angiogenesis, the process of new blood vessel formation, is the key event in the mechanism of several pathological processes… 
Highly Cited
2003
Highly Cited
2003
The metabolism of sulindac enhances its scavenging activity against reactive oxygen and nitrogen species.
Highly Cited
2000
Highly Cited
2000
Sulindac and exisulind exhibit a significant antiproliferative effect and induce apoptosis in human hepatocellular carcinoma cell lines.
This is the first report enumerating a superb antiproliferative effect of both sulindac and exisulind on hepatocellular cancer… 
1999
1999
Effects of sulindac, sulindac metabolites, and aspirin on the activity of detoxification enzymes in HT-29 human colon adenocarcinoma cells.
Review
1994
Review
1994
Strategy and planning for chemopreventive drug development: Clinical development plans
At the National Cancer Institute, Division of Cancer Prevention and Control, the Chemoprevention Branch and Agent Development… 
1980
1980
The antiinflammatory activity of analogs of indomethacin correlates with their inhibitory effects on phospholipase A2 of rabbit polymorphonuclear leukocytes.
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