sulindac sulfone

Known as: (Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic Acid, Exisulind 
An inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. After oral administration, sulindac undergoes extensive… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1982-2017
051019822017

Related topics

Related topics

8 relations

Broader (4)

Anticarcinogenic AgentsAntineoplastic AgentsCyclooxygenase InhibitorsSulindac

Narrower (3)

AptosynCP248FGN-1
analogs & derivatives

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
sulindac sulfone
Antineoplastic Agents
Cyclooxygenase Inhibitors
Sulindac
Anticarcinogenic Agents
CP248

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer.
Sulindac, a non-steroidal anti-inflammatory prodrug, is metabolized into pharmacologically active sulfide and sulfone derivatives… (More)
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Highly Cited
1999
Highly Cited
1999
Sulindac inhibits activation of the NF-kappaB pathway.
Sulindac is a non-steroidal anti-inflammatory agent that is related both structurally and pharmacologically to indomethacin. In… (More)
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Highly Cited
1999
Highly Cited
1999
Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines.
We examined the activity of two metabolites of sulindac (a nonsteroidal anti-inflammatory drug), sulindac sulfide and sulindac… (More)
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1999
1999
Sulindac sulfone induced regression of rectal polyps in patients with familial adenomatous polyposis.
Sulindac sulfone (Exisulind), a metabolite of the non-steroidal anti-inflammatory drug, sulindac, was evalauted for its effects… (More)
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1999
1999
Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis.
OBJECTIVES Recent studies have shown that Exisulind, a sulfone metabolite of the nonsteroidal anti-inflammatory drug (NSAID… (More)
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1999
1999
Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of administration during carcinogenic process.
Epidemiological and model studies with laboratory animals have provided evidence that nonsteroidal anti-inflammatory drugs reduce… (More)
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1999
1999
Sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growth.
Sulindac sulfide, a metabolite of the nonsteroidal antiinflammatory drug (NSAID) sulindac sulfoxide, is effective at reducing… (More)
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1998
1998
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone).
The sulfone derivative of the non-steroidal anti-inflammatory drug (NSAID), sulindac, has been reported to inhibit mammary and… (More)
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Highly Cited
1997
Highly Cited
1997
Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as sulindac, have cancer chemopreventive properties by a mechanism that has… (More)
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Highly Cited
1997
Highly Cited
1997
Sulfone metabolite of sulindac inhibits mammary carcinogenesis.
Sulindac sulfoxide, a commonly prescribed anti-inflammatory drug, has cancer chemopreventive activity. During its metabolism, the… (More)
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