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sulindac sulfone

Known as: (Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic Acid, Exisulind 
An inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. After oral administration, sulindac undergoes extensive… Expand
National Institutes of Health

Related topics

Related topics

9 relations

Broader (4)

Anticarcinogenic AgentsAntineoplastic AgentsCyclooxygenase InhibitorsSulindac

Narrower (3)

AptosynCP248FGN-1
analogs & derivativescarboplatin/exisulind/gemcitabine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice
Significance Cerebral cavernous malformation (CCM) disease can lead to brain hemorrhages, seizures, and paralysis. No… Expand
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Review
2007
Review
2007
The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels.
PDE5 is a key enzyme involved in the regulation of cGMP-specific signaling pathways in normal physiological processes such as… Expand
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Highly Cited
2003
Highly Cited
2003
Cyclooxygenase-independent Induction of Apoptosis by Sulindac Sulfone Is Mediated by Polyamines in Colon Cancer*
Sulindac, a non-steroidal anti-inflammatory prodrug, is metabolized into pharmacologically active sulfide and sulfone derivatives… Expand
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Highly Cited
2000
Highly Cited
2000
Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1.
Sulindac sulfone (Exisulind) induces apoptosis and exhibits cancer chemopreventive activity, but in contrast to sulindac, it does… Expand
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Highly Cited
1999
Highly Cited
1999
Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis.
OBJECTIVES Recent studies have shown that Exisulind, a sulfone metabolite of the nonsteroidal anti-inflammatory drug (NSAID… Expand
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Highly Cited
1999
Highly Cited
1999
Sulindac inhibits activation of the NF-kappaB pathway.
Sulindac is a non-steroidal anti-inflammatory agent that is related both structurally and pharmacologically to indomethacin. In… Expand
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Highly Cited
1999
Highly Cited
1999
Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines.
We examined the activity of two metabolites of sulindac (a nonsteroidal anti-inflammatory drug), sulindac sulfide and sulindac… Expand
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Highly Cited
1999
Highly Cited
1999
Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of administration during carcinogenic process.
Epidemiological and model studies with laboratory animals have provided evidence that nonsteroidal anti-inflammatory drugs reduce… Expand
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Highly Cited
1997
Highly Cited
1997
Sulfone metabolite of sulindac inhibits mammary carcinogenesis.
Sulindac sulfoxide, a commonly prescribed anti-inflammatory drug, has cancer chemopreventive activity. During its metabolism, the… Expand
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Highly Cited
1997
Highly Cited
1997
Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as sulindac, have cancer chemopreventive properties by a mechanism that has… Expand
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