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sulindac sulfone

Known as: (Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic Acid, Exisulind 
An inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. After oral administration, sulindac undergoes extensive… 
National Institutes of Health

Papers overview

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Review
2007
Review
2007
  • B. ZhuS. Strada
  • Current Topics in Medicinal Chemistry
  • 2007
  • Corpus ID: 25922362
PDE5 is a key enzyme involved in the regulation of cGMP-specific signaling pathways in normal physiological processes such as… 
Highly Cited
2004
Highly Cited
2004
Purpose: Epidemiologic studies have revealed a decreased risk of colon cancer among people who have regularly taken… 
Highly Cited
2003
Highly Cited
2003
Sulindac, a non-steroidal anti-inflammatory prodrug, is metabolized into pharmacologically active sulfide and sulfone derivatives… 
Highly Cited
2001
Highly Cited
2001
Exisulind (Aptosyn) is a novel antineoplastic drug being developed for the prevention and treatment of precancerous and malignant… 
Highly Cited
2000
Highly Cited
2000
This is the first report enumerating a superb antiproliferative effect of both sulindac and exisulind on hepatocellular cancer… 
Highly Cited
2000
Highly Cited
2000
Sulindac sulfone (exisulind), although a nonsteroidal anti-inflammatory drug derivative, induces apoptosis in tumor cells by a… 
Highly Cited
1999
Highly Cited
1999
Highly Cited
1999
Sulindac is a non-steroidal anti-inflammatory agent that is related both structurally and pharmacologically to indomethacin. In… 
Highly Cited
1997
Highly Cited
1997
Sulindac sulfoxide, a commonly prescribed anti-inflammatory drug, has cancer chemopreventive activity. During its metabolism, the… 
Highly Cited
1997
Highly Cited
1997
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as sulindac, have cancer chemopreventive properties by a mechanism that has…