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sulindac sulfone

Known as: (Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic Acid, Exisulind 
An inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. After oral administration, sulindac undergoes extensive… Expand
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
Purpose: Epidemiologic studies have revealed a decreased risk of colon cancer among people who have regularly taken… Expand
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Highly Cited
2003
Highly Cited
2003
Sulindac, a non-steroidal anti-inflammatory prodrug, is metabolized into pharmacologically active sulfide and sulfone derivatives… Expand
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Highly Cited
2001
Highly Cited
2001
PURPOSE We evaluated the safety and efficacy of exisulind for delaying disease progression in men with increasing prostate… Expand
Highly Cited
2001
Highly Cited
2001
Exisulind (Aptosyn) is a novel antineoplastic drug being developed for the prevention and treatment of precancerous and malignant… Expand
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Highly Cited
2000
Highly Cited
2000
Sulindac sulfone (exisulind), although a nonsteroidal anti-inflammatory drug derivative, induces apoptosis in tumor cells by a… Expand
Highly Cited
1999
Highly Cited
1999
OBJECTIVES Recent studies have shown that Exisulind, a sulfone metabolite of the nonsteroidal anti-inflammatory drug (NSAID… Expand
Highly Cited
1999
Highly Cited
1999
We examined the activity of two metabolites of sulindac (a nonsteroidal anti-inflammatory drug), sulindac sulfide and sulindac… Expand
Highly Cited
1999
Highly Cited
1999
Sulindac is a non-steroidal anti-inflammatory agent that is related both structurally and pharmacologically to indomethacin. In… Expand
Highly Cited
1997
Highly Cited
1997
Sulindac sulfoxide, a commonly prescribed anti-inflammatory drug, has cancer chemopreventive activity. During its metabolism, the… Expand
Highly Cited
1997
Highly Cited
1997
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as sulindac, have cancer chemopreventive properties by a mechanism that has… Expand
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