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sulindac sulfone

Known as: (Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic Acid, Exisulind 
An inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. After oral administration, sulindac undergoes extensive… Expand
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Significance Cerebral cavernous malformation (CCM) disease can lead to brain hemorrhages, seizures, and paralysis. No… Expand
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Review
2007
Review
2007
PDE5 is a key enzyme involved in the regulation of cGMP-specific signaling pathways in normal physiological processes such as… Expand
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Highly Cited
2003
Highly Cited
2003
Sulindac, a non-steroidal anti-inflammatory prodrug, is metabolized into pharmacologically active sulfide and sulfone derivatives… Expand
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Highly Cited
2000
Highly Cited
2000
Sulindac sulfone (Exisulind) induces apoptosis and exhibits cancer chemopreventive activity, but in contrast to sulindac, it does… Expand
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Highly Cited
1999
Highly Cited
1999
OBJECTIVES Recent studies have shown that Exisulind, a sulfone metabolite of the nonsteroidal anti-inflammatory drug (NSAID… Expand
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Highly Cited
1999
Highly Cited
1999
Sulindac is a non-steroidal anti-inflammatory agent that is related both structurally and pharmacologically to indomethacin. In… Expand
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Highly Cited
1999
Highly Cited
1999
We examined the activity of two metabolites of sulindac (a nonsteroidal anti-inflammatory drug), sulindac sulfide and sulindac… Expand
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Highly Cited
1999
Highly Cited
1999
Epidemiological and model studies with laboratory animals have provided evidence that nonsteroidal anti-inflammatory drugs reduce… Expand
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Highly Cited
1997
Highly Cited
1997
Sulindac sulfoxide, a commonly prescribed anti-inflammatory drug, has cancer chemopreventive activity. During its metabolism, the… Expand
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Highly Cited
1997
Highly Cited
1997
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as sulindac, have cancer chemopreventive properties by a mechanism that has… Expand
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