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sulindac sulfone
Known as:
(Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic Acid
, Exisulind
An inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. After oral administration, sulindac undergoes extensive…
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National Institutes of Health
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Related topics
Related topics
9 relations
Broader (4)
Anticarcinogenic Agents
Antineoplastic Agents
Cyclooxygenase Inhibitors
Sulindac
Narrower (3)
Aptosyn
CP248
FGN-1
analogs & derivatives
carboplatin/exisulind/gemcitabine
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels.
B. Zhu
,
S. Strada
Current Topics in Medicinal Chemistry
2007
Corpus ID: 25922362
PDE5 is a key enzyme involved in the regulation of cGMP-specific signaling pathways in normal physiological processes such as…
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Highly Cited
2004
Highly Cited
2004
Regression of Mouse Prostatic Intraepithelial Neoplasia by Nonsteroidal Anti-inflammatory Drugs in the Transgenic Adenocarcinoma Mouse Prostate Model
B. Narayanan
,
N. Narayanan
,
B. Pittman
,
Bandaru S. Reddy
Clinical Cancer Research
2004
Corpus ID: 15688527
Purpose: Epidemiologic studies have revealed a decreased risk of colon cancer among people who have regularly taken…
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Highly Cited
2003
Highly Cited
2003
Cyclooxygenase-independent Induction of Apoptosis by Sulindac Sulfone Is Mediated by Polyamines in Colon Cancer*
N. Babbar
,
N. Ignatenko
,
R. Casero
,
E. Gerner
Journal of Biological Chemistry
2003
Corpus ID: 41155017
Sulindac, a non-steroidal anti-inflammatory prodrug, is metabolized into pharmacologically active sulfide and sulfone derivatives…
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Highly Cited
2001
Highly Cited
2001
Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis.
G. Piazza
,
W. Thompson
,
+9 authors
C. Grubbs
Cancer Research
2001
Corpus ID: 1665511
Exisulind (Aptosyn) is a novel antineoplastic drug being developed for the prevention and treatment of precancerous and malignant…
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Highly Cited
2000
Highly Cited
2000
Sulindac and exisulind exhibit a significant antiproliferative effect and induce apoptosis in human hepatocellular carcinoma cell lines.
M. Rahman
,
D. Dhar
,
R. Masunaga
,
A. Yamanoi
,
H. Kohno
,
N. Nagasue
Cancer Research
2000
Corpus ID: 12391010
This is the first report enumerating a superb antiproliferative effect of both sulindac and exisulind on hepatocellular cancer…
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Highly Cited
2000
Highly Cited
2000
Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.
W. Thompson
,
G. Piazza
,
+6 authors
R. Pamukcu
Cancer Research
2000
Corpus ID: 37115465
Sulindac sulfone (exisulind), although a nonsteroidal anti-inflammatory drug derivative, induces apoptosis in tumor cells by a…
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Highly Cited
1999
Highly Cited
1999
Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines.
J. T. Lim
,
G. Piazza
,
+10 authors
I. Weinstein
Biochemical Pharmacology
1999
Corpus ID: 26537988
Highly Cited
1999
Highly Cited
1999
Sulindac inhibits activation of the NF-kappaB pathway.
Y. Yamamoto
,
M. Yin
,
K. -. Lin
,
R. Gaynor
Journal of Biological Chemistry
1999
Corpus ID: 24195385
Sulindac is a non-steroidal anti-inflammatory agent that is related both structurally and pharmacologically to indomethacin. In…
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Highly Cited
1997
Highly Cited
1997
Sulfone metabolite of sulindac inhibits mammary carcinogenesis.
H. Thompson
,
C. Jiang
,
+5 authors
D. Ahnen
Cancer Research
1997
Corpus ID: 19317015
Sulindac sulfoxide, a commonly prescribed anti-inflammatory drug, has cancer chemopreventive activity. During its metabolism, the…
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Highly Cited
1997
Highly Cited
1997
Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.
G. Piazza
,
D. Alberts
,
+13 authors
R. Pamukcu
Cancer Research
1997
Corpus ID: 2608926
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as sulindac, have cancer chemopreventive properties by a mechanism that has…
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