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sulindac sulfone
Known as:
(Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic Acid
, Exisulind
An inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. After oral administration, sulindac undergoes extensive…
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National Institutes of Health
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Related topics
Related topics
9 relations
Broader (4)
Anticarcinogenic Agents
Antineoplastic Agents
Cyclooxygenase Inhibitors
Sulindac
Narrower (3)
Aptosyn
CP248
FGN-1
analogs & derivatives
carboplatin/exisulind/gemcitabine
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Phase II Evaluation of Docetaxel Plus Exisulind in Patients With Androgen Independent Prostate Carcinoma
V. Sinibaldi
,
K. Elza-Brown
,
+8 authors
M. Carducci
American Journal of Clinical Oncology
2006
Corpus ID: 24123011
Objectives:In this phase II study, the combination of docetaxel and exisulind (a GMP phosphodiesterase inhibitor) was given to…
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2006
2006
Capillary electrophoresis combining field-amplified sample stacking and electroosmotic flow suppressant for analysis of sulindac and its two metabolites in plasma.
Yen-Ling Chen
,
Y. Jong
,
Shou‐Mei Wu
Journal of Chromatography A
2006
Corpus ID: 21332458
2005
2005
A phase I/II dose‐escalation study of exisulind and docetaxel in patients with hormone‐refractory prostate cancer
C. Ryan
,
W. Stadler
,
N. Vogelzang
BJU International
2005
Corpus ID: 21476380
To determine the safety and efficacy, in a dose‐escalation study, of exisulind (an oral sulphone metabolite of sulindac thought…
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2005
2005
Sulindac Sulfone Is Most Effective in Modulating β‐Catenin‐Mediated Transcription in Cells with Mutant APC
Wen‐chi Chang
,
L. Everley
,
G. Pfeiffer
,
H. Cooper
,
A. Barusevicius
,
M. Clapper
Annals of the New York Academy of Sciences
2005
Corpus ID: 40503281
Abstract: Sulindac sulfone (FGN‐1, Aptosyn), a metabolite of the nonsteroidal anti‐inflammatory drug sulindac, lacks…
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2004
2004
Suppression of angiogenic activity of sera from diabetic patients with non-proliferative retinopathy by compounds of herbal origin and sulindac sulfone.
P. Skopiński
,
J. Szaflik
,
+5 authors
E. Skopińska-Różewska
International Journal of Molecular Medicine
2004
Corpus ID: 27976320
Angiogenesis, the process of new blood vessel formation, is the key event in the mechanism of several pathological processes…
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Highly Cited
2003
Highly Cited
2003
The metabolism of sulindac enhances its scavenging activity against reactive oxygen and nitrogen species.
E. Fernandes
,
Sofia A Toste
,
J. Lima
,
S. Reis
Free Radical Biology & Medicine
2003
Corpus ID: 43414048
Highly Cited
2000
Highly Cited
2000
Sulindac and exisulind exhibit a significant antiproliferative effect and induce apoptosis in human hepatocellular carcinoma cell lines.
Atiqur Rahman
,
D. Dhar
,
R. Masunaga
,
A. Yamanoi
,
H. Kohno
,
Naofumi Nagasue
Cancer Research
2000
Corpus ID: 12391010
This is the first report enumerating a superb antiproliferative effect of both sulindac and exisulind on hepatocellular cancer…
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1999
1999
Effects of sulindac, sulindac metabolites, and aspirin on the activity of detoxification enzymes in HT-29 human colon adenocarcinoma cells.
E. J. Patten
,
M. Delong
Cancer Letters
1999
Corpus ID: 39087070
Review
1994
Review
1994
Strategy and planning for chemopreventive drug development: Clinical development plans
MD Gary J. Kelloff
,
PhD James A. Crowell
,
+13 authors
PhD5 Caroline C. Sigman
1994
Corpus ID: 28557431
At the National Cancer Institute, Division of Cancer Prevention and Control, the Chemoprevention Branch and Agent Development…
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1980
1980
The antiinflammatory activity of analogs of indomethacin correlates with their inhibitory effects on phospholipase A2 of rabbit polymorphonuclear leukocytes.
L. Kaplan-Harris
,
P. Elsbach
Biochimica et Biophysica Acta
1980
Corpus ID: 31439262
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