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sulfonyl-pyridazinone inhibitor

 
National Institutes of Health

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PyridazinesSulfones

Papers overview

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2019
2019
A new series of pyridazinone derivatives as cholinesterases inhibitors: Synthesis, in vitro activity and molecular modeling studies.
BACKGROUND The pyridazinone nucleus has been incorporated into a wide variety of therapeutically interesting molecules to… Expand
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2018
2018
A new compound of thiophenylated pyridazinone IMB5043 showing potent antitumor efficacy through ATM-Chk2 pathway
Through cell-based screening models, we have identified a new compound IMB5043, a thiophenylated pyridazinone, which exerted… Expand
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2017
2017
Lewis base-catalyzed diastereoselective [3 + 2] cycloaddition reaction of nitrones with electron-deficient alkenes: an access to isoxazolidine derivatives
A Lewis base-catalyzed [3 + 2] cycloaddition reaction of nitrones with electron-deficient alkenes has been achieved under mild… Expand
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Review
2017
Review
2017
Correspondence: Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury
In a recent publication1 Qin and co-workers report the biological evaluation of compound 17b2, also referred as (±)−5a3, a chiral… Expand
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2013
2013
Composé pyridazinone et utilisation associée
La presente invention concerne un compose pyridazinone de formule (I) et son utilisation comme activateur de resistance induite… Expand
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2013
2013
[Cases of successful treatment of heart failure after cardiac surgeries].
UNLABELLED Low cardiac output syndrome (LCOS) is a leader in the structure of complications and mortality in patients after… Expand
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2010
2010
Abstract 5777: EMD 1214063, an exquisitely selective c-Met kinase inhibitor in clinical phase 1
The role of the receptor tyrosin kinase c-Met in tumor progression, metastasis and aggressiveness has been convincingly… Expand
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2006
2006
Derive de pyrazolopyridine-4-yl-pyridazinone, sel d’addition de ce derive et inhibiteur des pde comprenant ce sel ou derive en tant qu’ingredient actif
Le probleme a resoudre dans le cadre de la presente invention consiste a proposer un nouveau derive de pyrazolopyridine-4-yl… Expand
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2001
2001
Synthesis, biological evaluation, and pharmacophore generation of new pyridazinone derivatives with affinity toward alpha(1)- and alpha(2)-adrenoceptors.
A series of new pyridazin-3(2H)-one derivatives (3 and 4) were evaluated for their in vitro affinity toward both alpha(1)- and… Expand
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1986
1986
UDCG 115 a benzimidazo-pyridazinone compound with cardiovascular activity inhibits platelet thrombus formation
 
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