sulfonyl-pyridazinone inhibitor

National Institutes of Health

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2013

2013

[Cases of successful treatment of heart failure after cardiac surgeries].

G V Lobacheva, B A Abdugapparov, Fakhraddin Abasov
Anesteziologiia i reanimatologiia
2013

UNLABELLED Low cardiac output syndrome (LCOS) is a leader in the structure of complications and mortality in patients after… (More)

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2011

2011

Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast.

Robert W Allcock, Haakon Blakli, +6 authors David R Adams
Bioorganic & medicinal chemistry letters
2011

Ibudilast [1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one] is a nonselective phosphodiesterase inhibitor used… (More)

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2011

2011

A "click and activate" approach in one-pot synthesis of a triazolyl-pyridazinone library.

Wenyuan Qian, David J Winternheimer, Jennifer Allen
Organic letters
2011

A "click and activate" strategy was designed and executed in a four-component, stepwise condensation that led to a trisubstituted… (More)

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2001

2001

Synthesis, biological evaluation, and pharmacophore generation of new pyridazinone derivatives with affinity toward alpha(1)- and alpha(2)-adrenoceptors.

Ryan P Barbaro, Lia Betti, +6 authors Stefano Corsano
Journal of medicinal chemistry
2001

A series of new pyridazin-3(2H)-one derivatives (3 and 4) were evaluated for their in vitro affinity toward both alpha(1)- and… (More)

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1988

1988

Effects of pimobendan (UD-CG 115 BS), a new positive inotropic agent, on ventricular tachycardia and ischemic ventricular fibrillation in a conscious canine model of recent myocardial infarction.

J. J. Lynch, Jos J. E. M. Kitzen, P T Hoff, B. R. Lucchesi
Journal of cardiovascular pharmacology
1988

Pimobendan (UD-CG 115 BS; 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl- 3(2H)- pyridazinone) is a newly… (More)

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1984

1984

Effect on contractility of skinned fibres from mammalian heart and smooth muscle by a new benzimidazole derivative, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methy l-3(2H…

J Caspar Rüegg, Gabriele Pfitzer, D Eubler, C. Zeugner
Arzneimittel-Forschung
1984

The positive inotropic drug 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]methyl-3(2 H)- pyridazinone (UD-CG 115 BS… (More)

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