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Hypersensitivity adverse drug reactions are much more common among patients with acquired immunodeficiency syndrome (AIDS) than… Expand Sulphonamide idiosyncratic toxicosis has been reported in 28 dogs. Non-septic polyarthritis and fever occurring after 8 to 21… Expand Abstract.Objective: To determine whether the antiprotozoal drug atovaquone inhibits the cytochrome P450 (CYP)2C9-mediated… Expand Sulphamethoxazole has been associated with the occurrence of hypersensitivity reactions. There is controversy as to whether the… Expand Cutaneous reactions are the most common manifestation of delayed-type hypersensitivity caused by sulfamethoxazole and dapsone. In… Expand 1. Reduction of hydroxylamine drug metabolites by NADH-dependent hydroxylamine reductase (NDHR) has been suggested to be involved… Expand Sulphamethoxazole undergoes CYP2C9-mediated bioactivation to a hydroxylamine. In this study, we investigated the effect of the… Expand Sulfamethoxazole toxicity is putatively initiated by the formation of a hydroxylamine metabolite by cytochromes P450. If this… Expand 1. Cytochrome P450-mediated bioactivation of sulphamethoxazole to a hydroxylamine has been implicated in the hypersensitivity… Expand The formation and elimination of sulphamethoxazole hydroxylamine in relation to the pharmacokinetics of the parent compound and… Expand