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squalene monooxygenase activity

Known as: squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity, squalene-2,3-epoxidase activity, squalene oxydocyclase activity 
Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+). [RHEA:25285]
National Institutes of Health

Papers overview

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2015
2015
Lower Squalene Epoxidase and Higher Scavenger Receptor Class B Type 1 Protein Levels Are Involved in Reduced Serum Cholesterol Levels in Stroke-Prone Spontaneously Hypertensive Rats.
A lower serum cholesterol level was recently shown to be one of the causes of stroke in an epidemiological study. Spontaneously… 
2005
2005
Characterizing Sterol Defect Suppressors Uncovers a Novel Transcriptional Signaling Pathway Regulating Zymosterol Biosynthesis*
erg26-1ts cells harbor defects in the 4α-carboxysterol-C3 dehydrogenase activity necessary for conversion of 4,4… 
2004
2004
Role of skin surface lipids in UV-induced epidermal cell changes
SummaryUltraviolet irradiation is capable of affecting skin surface lipids, especially squalene and cholesterol, both in vitro… 
2002
2002
Effect of squalene monohydroperoxide on cytotoxicity and cytokine release in a three-dimensional human skin model and human epidermal keratinocytes.
In order to clarify that squalene monohydroperoxide (SQOOH) correlates with changes in morphology through cytotoxicity and… 
Highly Cited
1996
Highly Cited
1996
Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents
Squalene epoxidase (SE) is the primary target of the allylamine antimycotic agents terbinafine and naftifine and also of the… 
Highly Cited
1991
Highly Cited
1991
Tellurium Blocks Cholesterol Synthesis by Inhibiting Squalene Metabolism: Preferential Vulnerability to This Metabolic Block Leads to Peripheral Nervous System Demyelination
Inclusion of 1.1% elemental tellurium in the diet of postweanling rats produces a peripheral neuropathy due to a highly… 
Highly Cited
1990
Highly Cited
1990
Regulation of squalene epoxidase in HepG2 cells.
1990
1990
Regulation of squalene epoxidase activity in rat liver.
Regulation of squalene epoxidase activity was examined in rat hepatic microsomes. The hepatic squalene epoxidase activity was… 
1987
1987
Regulation of squalene epoxidase activity and comparison of catalytic properties of rat liver and Chinese hamster ovary cell-derived enzymes.
Squalene epoxidase activity has been studied in cell-free preparations of Chinese hamster ovary (CHO) cells and rat liver. In… 
1983
1983
Intermembrane transfer of squalene promoted by supernatant protein factor.
Supernatant protein factor (SPF), a protein that stimulates squalene epoxidation, mediates the transfer of squalene between two… 
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