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squalene monooxygenase activity
Known as:
squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity
, squalene-2,3-epoxidase activity
, squalene oxydocyclase activity
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Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+). [RHEA:25285]
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Lower Squalene Epoxidase and Higher Scavenger Receptor Class B Type 1 Protein Levels Are Involved in Reduced Serum Cholesterol Levels in Stroke-Prone Spontaneously Hypertensive Rats.
A. Michihara
,
Mayuko Mido
,
H. Matsuoka
,
Yurika Mizutani
Biological & pharmaceutical bulletin
2015
Corpus ID: 25974756
A lower serum cholesterol level was recently shown to be one of the causes of stroke in an epidemiological study. Spontaneously…
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2005
2005
Characterizing Sterol Defect Suppressors Uncovers a Novel Transcriptional Signaling Pathway Regulating Zymosterol Biosynthesis*
M. Germann
,
Christina Gallo
,
+9 authors
J. Nickels
Journal of Biological Chemistry
2005
Corpus ID: 46407807
erg26-1ts cells harbor defects in the 4α-carboxysterol-C3 dehydrogenase activity necessary for conversion of 4,4…
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2004
2004
Role of skin surface lipids in UV-induced epidermal cell changes
M. Picardo
,
C. Zompetta
,
+5 authors
G. Prota
Archives of Dermatological Research
2004
Corpus ID: 412257
SummaryUltraviolet irradiation is capable of affecting skin surface lipids, especially squalene and cholesterol, both in vitro…
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2002
2002
Effect of squalene monohydroperoxide on cytotoxicity and cytokine release in a three-dimensional human skin model and human epidermal keratinocytes.
T. Uchino
,
H. Tokunaga
,
H. Onodera
,
M. Ando
Biological & pharmaceutical bulletin
2002
Corpus ID: 25040176
In order to clarify that squalene monohydroperoxide (SQOOH) correlates with changes in morphology through cytotoxicity and…
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Highly Cited
1996
Highly Cited
1996
Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents
B. Favre
,
N. Ryder
Antimicrobial agents and chemotherapy
1996
Corpus ID: 44321746
Squalene epoxidase (SE) is the primary target of the allylamine antimycotic agents terbinafine and naftifine and also of the…
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Highly Cited
1991
Highly Cited
1991
Tellurium Blocks Cholesterol Synthesis by Inhibiting Squalene Metabolism: Preferential Vulnerability to This Metabolic Block Leads to Peripheral Nervous System Demyelination
M. Wagner-Recio
,
A. Toews
,
P. Morell
Journal of neurochemistry
1991
Corpus ID: 20284791
Inclusion of 1.1% elemental tellurium in the diet of postweanling rats produces a peripheral neuropathy due to a highly…
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Highly Cited
1990
Highly Cited
1990
Regulation of squalene epoxidase in HepG2 cells.
Y. Hidaka
,
T. Satoh
,
T. Kamei
Journal of lipid research
1990
Corpus ID: 9365628
1990
1990
Regulation of squalene epoxidase activity in rat liver.
T. Satoh
,
Y. Hidaka
,
T. Kamei
Journal of lipid research
1990
Corpus ID: 20006366
Regulation of squalene epoxidase activity was examined in rat hepatic microsomes. The hepatic squalene epoxidase activity was…
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1987
1987
Regulation of squalene epoxidase activity and comparison of catalytic properties of rat liver and Chinese hamster ovary cell-derived enzymes.
H. Eilenberg
,
I. Shechter
Journal of lipid research
1987
Corpus ID: 8622213
Squalene epoxidase activity has been studied in cell-free preparations of Chinese hamster ovary (CHO) cells and rat liver. In…
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1983
1983
Intermembrane transfer of squalene promoted by supernatant protein factor.
D. Fuks-Holmberg
,
K. Bloch
Journal of lipid research
1983
Corpus ID: 43341245
Supernatant protein factor (SPF), a protein that stimulates squalene epoxidation, mediates the transfer of squalene between two…
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