sphingosine cholinephosphotransferase activity
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The Hippo pathway is crucial in organ size control, and its dysregulation contributes to tumorigenesis. However, upstream signals… Expand Ceramidase (CDase) catalyzes the hydrolysis of ceramide (Cer) to sphingosine (Sph) and fatty acid. We have reported the molecular… Expand The authors describe a novel multi-lamellar concentrate based on ceramide technology and newly identified cell-signalling… Expand The intracellular distribution of synthetic glycosphingolipids (GSLs) bearing a fluorophore can be monitored in living cells by… Expand [Reaction: see text]. Reaction of chiral guanidinium ylides with alpha,beta-unsaturated aldehydes gives 3-(alpha,beta-unsaturated… Expand An overexpression system was recently developed to produce and purify recombinant, human acid ceramidase. In addition to ceramide… Expand We have previously purified a membrane-bound ceramidase from rat brain and recently cloned the human homologue. We also observed… Expand Sphingosine has been shown to inhibit cell growth in many cell lines although the mechanism of this effect remains obscure. More… Expand The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine… Expand Abstract Our studies in vivo and in vitro on the biosynthesis and the degradation of long chain sphingosine bases allow now to… Expand