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sorbinil

Known as: (S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione, D-6-fluoro-spiro(chroman-4,4'-imidazolidine)-2',5'-dione, Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2',5'-dione, 6-fluoro-2,3-dihydro-, (S)- 
 
National Institutes of Health

Papers overview

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Review
2016
Review
2016
Diabetes mellitus occurrence has been associated to the modification of the physiological levels of glucose and is often… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Aldose reductase (AR) is an NADPH-dependent enzyme implicated in long-term diabetic complications. Buried at the… Expand
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Highly Cited
1994
Highly Cited
1994
Similar vascular pathological conditions are observed in diabetic animals and those with diet-induced hypergalactosemia. Both… Expand
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Highly Cited
1988
Highly Cited
1988
There is reason to believe that diabetic neuropathy may be related to the accumulation of sorbitol in nerve tissue through an… Expand
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Highly Cited
1984
Highly Cited
1984
Although enhanced activity of the polyol pathway has been implicated in the pathogenesis of certain complications of diabetes… Expand
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Highly Cited
1984
Highly Cited
1984
The small, but statistically significant, improvement in nerve conduction after treatment of diabetic patients with the aldose… Expand
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Highly Cited
1983
Highly Cited
1983
Normotensive and spontaneously hypertensive rats fed a 30% galactose diet until 15-21 months of age developed significant (P less… Expand
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Highly Cited
1983
Highly Cited
1983
A double-blind, randomized, placebo-controlled crossover trial of the aldose reductase inhibitor sorbinil was undertaken in 15… Expand
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Highly Cited
1982
Highly Cited
1982
Cataract formation in galactosemic rats was studied by ophthalmoscopy, slit-lamp biomicroscopy, and by light microscopy using… Expand
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Highly Cited
1979
Highly Cited
1979
In some tissues containing aldose reductase, increased flux through the polyol pathway has been implicated as being causative in… Expand
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