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sorbinil
Known as:
(S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione
, D-6-fluoro-spiro(chroman-4,4'-imidazolidine)-2',5'-dione
, Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2',5'-dione, 6-fluoro-2,3-dihydro-, (S)-
National Institutes of Health
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Related topics
Related topics
3 relations
Narrower (1)
CP 45634
Broader (2)
Imidazolidines
imidazoledione
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1986
Highly Cited
1986
Effect of hyperglycemia on sorbitol and myo-inositol content of cultured rat conceptus: failure of aldose reductase inhibitors to modify myo-inositol depletion and dysmorphogenesis.
Moshe Hod
,
Sara Star
,
J. Passonneau
,
T. Unterman
,
N. Freinkel
Biochemical and Biophysical Research…
1986
Corpus ID: 29698396
Highly Cited
1986
Highly Cited
1986
Hyperglycemia-induced activation of human erythrocyte aldose reductase and alterations in kinetic properties.
S. Srivastava
,
N. Ansari
,
G. Hair
,
J. Jaspan
,
M. Rao
,
B. Das
Biochimica et Biophysica Acta
1986
Corpus ID: 38483141
Highly Cited
1986
Highly Cited
1986
Experimental diabetes mellitus impairs the function of the retinal pigmented epithelium.
L. MacGregor
,
F. Matschinsky
Metabolism: Clinical and Experimental
1986
Corpus ID: 31097226
Highly Cited
1984
Highly Cited
1984
Red Blood Cell Sorbitol as an Indicator of Polyol Pathway Activity: Inhibition by Sorbinil in Insulin-dependent Diabetic Subjects
J. Malone
,
Hanzel Leavengood
,
Michael J Peterson
,
Mark M O'Brien
,
Michael G Page
,
C. Aldinger
Diabetes
1984
Corpus ID: 41883515
In a double-blind crossover study of 15 diabetic patients, elevated red blood cell (RBC) sorbitol levels were reduced by oral…
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Highly Cited
1983
Highly Cited
1983
Reversal of galactose cataract with Sorbinil in rats.
T. Hu
,
M. Datiles
,
J. Kinoshita
Investigative Ophthalmology and Visual Science
1983
Corpus ID: 42144203
Sorbinil, a potent aldose reductase inhibitor, can effectively block the progression of a galactose cataract even though the…
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Highly Cited
1983
Highly Cited
1983
The Effect of an Aldose Reductase Inhibitor (Sorbinil) on the Level of Metabolites in Lenses of Diabetic Rats
A. Gonzalez
,
M. Sochor
,
P. Mclean
Diabetes
1983
Corpus ID: 2338971
This study examined the effect of an aldose reductase inhibitor (Sorbinil, CP 45634,Pfizer, Sandwich, Kent, United Kingdom) on…
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Highly Cited
1983
Highly Cited
1983
Purification and characterization of two aldose reductase isoenzymes from rabbit muscle.
J. A. Cromlish
,
T. G. Flynn
Journal of Biological Chemistry
1983
Corpus ID: 38713806
Highly Cited
1982
Highly Cited
1982
Galactose cataract prevention with sorbinil, an aldose reductase inhibitor: a light microscopic study.
M. Datiles
,
H. Fukui
,
T. Kuwabara
,
J. Kinoshita
Investigative Ophthalmology and Visual Science
1982
Corpus ID: 1746834
Cataract formation in galactosemic rats was studied by ophthalmoscopy, slit-lamp biomicroscopy, and by light microscopy using…
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Highly Cited
1980
Highly Cited
1980
Role of nonenzymatic glycosylation in experimental cataract formation.
S. Chiou
,
L. Chylack
,
H. Bunn
,
J. Kinoshita
Biochemical and Biophysical Research…
1980
Corpus ID: 41373428
Highly Cited
1979
Highly Cited
1979
CP-45,634: a novel aldose reductase inhibitor that inhibits polyol pathway activity in diabetic and galactosemic rats.
M. Peterson
,
R. Sarges
,
C. Aldinger
,
D. MacDonald
Metabolism: Clinical and Experimental
1979
Corpus ID: 25077095
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