sorbinil

Known as: (S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione, D-6-fluoro-spiro(chroman-4,4'-imidazolidine)-2',5'-dione, Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2',5'-dione, 6-fluoro-2,3-dihydro-, (S)- 
 
National Institutes of Health

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2 relations

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CP 45634

Broader (1)

Imidazolidines

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Highly Cited
1997
Highly Cited
1997
A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil.
BACKGROUND Aldose reductase (AR) is an NADPH-dependent enzyme implicated in long-term diabetic complications. Buried at the… (More)
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1989
1989
Sorbinil prevents glomerular hyperperfusion in diabetic rats.
The role of polyol pathway metabolism in glomerular hyperperfusion of insulin-dependent diabetes mellitus (IDDM) was studied in… (More)
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Highly Cited
1988
Highly Cited
1988
Regeneration and repair of myelinated fibers in sural-nerve biopsy specimens from patients with diabetic neuropathy treated with sorbinil.
There is reason to believe that diabetic neuropathy may be related to the accumulation of sorbitol in nerve tissue through an… (More)
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1984
1984
Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil.
Although enhanced activity of the polyol pathway has been implicated in the pathogenesis of certain complications of diabetes… (More)
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1984
1984
Action of sorbinil in diabetic peripheral nerve. Relationship of polyol (sorbitol) pathway inhibition to a myo-inositol-mediated defect in sodium-potassium ATPase activity.
The small, but statistically significant, improvement in nerve conduction after treatment of diabetic patients with the aldose… (More)
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1984
1984
Clinical and neurophysiological studies with the aldose reductase inhibitor, sorbinil, in symptomatic diabetic neuropathy
The effect of sorbinil (200 mg daily for 4 weeks) was examined in 13 patients, mean age 59.7 years (range 42–72 years), with… (More)
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1984
1984
Prevention and reversal of defective axonal transport and motor nerve conduction velocity in rats with experimental diabetes by treatment with the aldose reductase inhibitor Sorbinil.
This investigation was designed to determine whether the aldose reductase inhibitor Sorbinil prevented the development of or… (More)
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1983
1983
Galactose-induced retinal capillary basement membrane thickening: prevention by Sorbinil.
Normotensive and spontaneously hypertensive rats fed a 30% galactose diet until 15-21 months of age developed significant (P less… (More)
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1983
1983
Inhibition of galactose-induced alterations in ocular lens with sorbinil.
Lens ultrastructure and Na- K-ATPase activity in the lenses of rats fed galactose and a galactose + sorbinil diet (aldose… (More)
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1982
1982
Galactose cataract prevention with sorbinil, an aldose reductase inhibitor: a light microscopic study.
Cataract formation in galactosemic rats was studied by ophthalmoscopy, slit-lamp biomicroscopy, and by light microscopy using… (More)
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