sorbinil

Known as: (S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione, D-6-fluoro-spiro(chroman-4,4'-imidazolidine)-2',5'-dione, Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2',5'-dione, 6-fluoro-2,3-dihydro-, (S)- 
 
National Institutes of Health

Papers overview

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Highly Cited
1997
Highly Cited
1997
BACKGROUND Aldose reductase (AR) is an NADPH-dependent enzyme implicated in long-term diabetic complications. Buried at the… (More)
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1989
1989
The role of polyol pathway metabolism in glomerular hyperperfusion of insulin-dependent diabetes mellitus (IDDM) was studied in… (More)
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Highly Cited
1988
Highly Cited
1988
There is reason to believe that diabetic neuropathy may be related to the accumulation of sorbitol in nerve tissue through an… (More)
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1984
1984
Although enhanced activity of the polyol pathway has been implicated in the pathogenesis of certain complications of diabetes… (More)
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1984
1984
The small, but statistically significant, improvement in nerve conduction after treatment of diabetic patients with the aldose… (More)
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1984
1984
The effect of sorbinil (200 mg daily for 4 weeks) was examined in 13 patients, mean age 59.7 years (range 42–72 years), with… (More)
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1984
1984
This investigation was designed to determine whether the aldose reductase inhibitor Sorbinil prevented the development of or… (More)
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1983
1983
Normotensive and spontaneously hypertensive rats fed a 30% galactose diet until 15-21 months of age developed significant (P less… (More)
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1983
1983
Lens ultrastructure and Na- K-ATPase activity in the lenses of rats fed galactose and a galactose + sorbinil diet (aldose… (More)
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1982
1982
Cataract formation in galactosemic rats was studied by ophthalmoscopy, slit-lamp biomicroscopy, and by light microscopy using… (More)
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