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sorbinil

Known as: (S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione, D-6-fluoro-spiro(chroman-4,4'-imidazolidine)-2',5'-dione, Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2',5'-dione, 6-fluoro-2,3-dihydro-, (S)- 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

CP 45634

Broader (2)

Imidazolidinesimidazoledione

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1986
Highly Cited
1986
Effect of hyperglycemia on sorbitol and myo-inositol content of cultured rat conceptus: failure of aldose reductase inhibitors to modify myo-inositol depletion and dysmorphogenesis.
Highly Cited
1986
Highly Cited
1986
Hyperglycemia-induced activation of human erythrocyte aldose reductase and alterations in kinetic properties.
Highly Cited
1986
Highly Cited
1986
Experimental diabetes mellitus impairs the function of the retinal pigmented epithelium.
Highly Cited
1984
Highly Cited
1984
Red Blood Cell Sorbitol as an Indicator of Polyol Pathway Activity: Inhibition by Sorbinil in Insulin-dependent Diabetic Subjects
In a double-blind crossover study of 15 diabetic patients, elevated red blood cell (RBC) sorbitol levels were reduced by oral… 
Highly Cited
1983
Highly Cited
1983
Reversal of galactose cataract with Sorbinil in rats.
Sorbinil, a potent aldose reductase inhibitor, can effectively block the progression of a galactose cataract even though the… 
Highly Cited
1983
Highly Cited
1983
The Effect of an Aldose Reductase Inhibitor (Sorbinil) on the Level of Metabolites in Lenses of Diabetic Rats
This study examined the effect of an aldose reductase inhibitor (Sorbinil, CP 45634,Pfizer, Sandwich, Kent, United Kingdom) on… 
Highly Cited
1983
Highly Cited
1983
Purification and characterization of two aldose reductase isoenzymes from rabbit muscle.
Highly Cited
1982
Highly Cited
1982
Galactose cataract prevention with sorbinil, an aldose reductase inhibitor: a light microscopic study.
Cataract formation in galactosemic rats was studied by ophthalmoscopy, slit-lamp biomicroscopy, and by light microscopy using… 
Highly Cited
1980
Highly Cited
1980
Role of nonenzymatic glycosylation in experimental cataract formation.
Highly Cited
1979
Highly Cited
1979
CP-45,634: a novel aldose reductase inhibitor that inhibits polyol pathway activity in diabetic and galactosemic rats.
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