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sorbinil

Known as: (S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione, D-6-fluoro-spiro(chroman-4,4'-imidazolidine)-2',5'-dione, Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2',5'-dione, 6-fluoro-2,3-dihydro-, (S)- 
 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

CP 45634

Broader (2)

Imidazolidinesimidazoledione

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Updates on Aldose Reductase Inhibitors for Management of Diabetic Complications and Non-diabetic Diseases.
Diabetes mellitus occurrence has been associated to the modification of the physiological levels of glucose and is often… Expand
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Highly Cited
1997
Highly Cited
1997
A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil.
BACKGROUND Aldose reductase (AR) is an NADPH-dependent enzyme implicated in long-term diabetic complications. Buried at the… Expand
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Highly Cited
1994
Highly Cited
1994
Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia
Similar vascular pathological conditions are observed in diabetic animals and those with diet-induced hypergalactosemia. Both… Expand
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Highly Cited
1988
Highly Cited
1988
Regeneration and repair of myelinated fibers in sural-nerve biopsy specimens from patients with diabetic neuropathy treated with sorbinil.
There is reason to believe that diabetic neuropathy may be related to the accumulation of sorbitol in nerve tissue through an… Expand
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Highly Cited
1984
Highly Cited
1984
Glomerular Polyol Accumulation in Diabetes and its Prevention by Oral Sorbinil
Although enhanced activity of the polyol pathway has been implicated in the pathogenesis of certain complications of diabetes… Expand
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Highly Cited
1984
Highly Cited
1984
Action of Sorbinil in Diabetic Peripheral Nerve: Relationship of Polyol (Sorbitol) Pathway Inhibition to a myo-Inositol-mediated Defect in Sodium-Potassium ATPase Activity
The small, but statistically significant, improvement in nerve conduction after treatment of diabetic patients with the aldose… Expand
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Highly Cited
1983
Highly Cited
1983
Galactose-induced retinal capillary basement membrane thickening: prevention by Sorbinil.
Normotensive and spontaneously hypertensive rats fed a 30% galactose diet until 15-21 months of age developed significant (P less… Expand
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Highly Cited
1983
Highly Cited
1983
A Controlled Trial of Sorbinil, an Aldose Reductase Inhibitor, in Chronic Painful Diabetic Neuropathy
A double-blind, randomized, placebo-controlled crossover trial of the aldose reductase inhibitor sorbinil was undertaken in 15… Expand
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Highly Cited
1982
Highly Cited
1982
Galactose cataract prevention with sorbinil, an aldose reductase inhibitor: a light microscopic study.
Cataract formation in galactosemic rats was studied by ophthalmoscopy, slit-lamp biomicroscopy, and by light microscopy using… Expand
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Highly Cited
1979
Highly Cited
1979
CP-45,634: a novel aldose reductase inhibitor that inhibits polyol pathway activity in diabetic and galactosemic rats.
In some tissues containing aldose reductase, increased flux through the polyol pathway has been implicated as being causative in… Expand
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