soluble guanylyl cyclase

Known as: Oxide Receptor, Nitric, Receptor, Nitric Oxide, Nitric Oxide Receptor 
A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like… (More)
National Institutes of Health

Papers overview

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2005
2005
Soluble guanylyl cyclase (sGC) is a cGMP-generating enzyme carrying a heme prosthetic group that functions as a nitric oxide (NO… (More)
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2005
2005
Soluble guanylyl cyclase is recognized as the most sensitive physiologic receptor for nitric oxide. Binding of nitric oxide to… (More)
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Highly Cited
2002
Highly Cited
2002
Functional evidence suggests that nitric oxide released from CA1 pyramidal cells can act as a retrograde messenger to mediate… (More)
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Highly Cited
2001
Highly Cited
2001
Nitric oxide (NO) is a widespread, potent, biological mediator that has many physiological and pathophysiological roles. Research… (More)
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Highly Cited
2000
Highly Cited
2000
Endogenously produced nitric oxide (NO) modulates nitrovasodilator-induced relaxation. We investigated the underlying mechanism… (More)
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Highly Cited
1999
Highly Cited
1999
Endothelial dysfunction, as observed in hypertension and atherosclerosis, is associated with a reduction in the bioavailability… (More)
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Highly Cited
1997
Highly Cited
1997
A guanylyl cyclase (GC-D) was recently shown to be expressed in a subclass of neurons within the neuroepithelim of the rat, but… (More)
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1995
1995
Soluble guanylyl cyclase is a heterodimer consisting of an alpha and beta subunit and stimulation occurs upon binding of NO to a… (More)
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Highly Cited
1995
Highly Cited
1995
The diffusible second messenger, nitric oxide, is synthesised in central neurons in response to activation of glutamate receptors… (More)
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Highly Cited
1989
Highly Cited
1989
A soluble enzyme obtained from rat forebrain catalyzes the NADPH-dependent formation of nitric oxide (NO) and citrulline from L… (More)
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