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sodium hydrogen S-(2-L-pyrrolidylmethyl) phosphorothioate

Known as: (S)-2-pyrrolidinemethanethiol, dihydrogen phosphorothioate, monosodium salt 
National Institutes of Health

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Pyrroles

Papers overview

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2013
2013
Effective Exon Skipping and Dystrophin Restoration by 2′-O-Methoxyethyl Antisense Oligonucleotide in Dystrophin-Deficient Mice
Antisense oligonucleotide (AO)–mediated exon-skipping therapy is one of the most promising therapeutic strategies for Duchenne… 
Review
2007
Review
2007
True antisense oligonucleotides with modified nucleotides restricted in the N-conformation.
As first-generation antisense oligonucleotides, more than a dozen phosphorothioate oligodeoxynucleotides (PS ODNs) have been… 
2004
2004
Impact of modifications of heterocyclic bases in CpG dinucleotides on their immune‐modulatory activity
Synthetic phosphorothioate oligodeoxynucleotides (ODN) bearing unmethylated CpG motifs can mimic the immune‐stimulatory effects… 
2001
2001
Photo-cross-linked oligonucleotide duplex as a decoy-DNA for inhibition of restriction endonuclease activity.
As a novel type of regulator molecule for DNA-recognizing proteins, a photo-cross-linked oligonucleotide duplex was designed and… 
1999
1999
Labeling of phosphorothioate antisense oligonucleotides with yttrium-90.
1998
1998
A comparison of guanosine-quartet inhibitory effects versus cytidine homopolymer inhibitory effects on rat neointimal formation.
Phosphorothioate oligodeoxynucleotides (PS oligos) manifest antisense and G-quartet aptameric inhibitory effects on vascular… 
Highly Cited
1990
Highly Cited
1990
Mechanisms of inhibition of herpes simplex virus type 2 growth by 28-mer phosphorothioate oligodeoxycytidine.
The 28-mer phosphorothioate oligodeoxycytidine (S-(dC)28) has been reported previously to be a strong inhibitor of herpes simplex… 
1986
1986
Stereoconfiguration markedly affects the biochemical and biological properties of phosphorothioate analogs of 2-5A core, (A2'p5')2A.
1984
1984
Genetic analysis of a Dictyostelium discoideum mutant resistant to adenosine 3':5'-cyclic phosphorothioate, an inhibitor of wild-type development
A mutant of Dictyostelium discoideum strain AX2 with altered responses to cyclic AMP has been analysed genetically. The mutant… 
1980
1980
Structure of the metal.nucleotide complex in the yeast phenylalanyl transfer ribonucleic acid synthetase reaction as determined with diastereomeric phosphorothioate analogs of ATP.
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