site of double-strand break

Known as: DNA damage foci, site of DSB, DNA damage focus 
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2001-2017
051020012017

Papers overview

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Highly Cited
2012
Highly Cited
2012
Following irradiation, numerous DNA-damage-responsive proteins rapidly redistribute into microscopically visible subnuclear… (More)
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2010
2010
The DNA double-strand break (DSB) is the most toxic form of DNA damage. Studies aimed at characterizing DNA repair during… (More)
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2010
2010
Relocalization of checkpoint proteins to chromatin flanking DNA double-strand breaks (DSBs) is critical for cellular responses to… (More)
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Highly Cited
2009
Highly Cited
2009
DNA double-strand breaks (DSBs) are highly cytotoxic lesions that are generated by ionizing radiation and various DNA-damaging… (More)
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2008
2008
DEAD box proteins are a family of putative RNA helicases associated with all aspects of cellular metabolism involving the… (More)
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2007
2007
In male germ cells the repair of DNA double strand breaks (DSBs) differs from that described for somatic cell lines. Irradiation… (More)
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Highly Cited
2006
Highly Cited
2006
Cellular responses to DNA damage involve the relocalization of checkpoint proteins to DNA double-strand breaks (DSBs). The… (More)
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Highly Cited
2003
Highly Cited
2003
Histone H2AX is rapidly phosphorylated in the chromatin micro-environment surrounding a DNA double-strand break (DSB). Although… (More)
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2003
2003
NFBD1/MDC1 (mediator of DNA damage checkpoint 1) is a nuclear factor with an amino-terminal FHA (forkhead-associated) domain and… (More)
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Highly Cited
2001
Highly Cited
2001
Fanconi anemia (FA) is a human autosomal recessive cancer susceptibility disorder characterized by cellular sensitivity to… (More)
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