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site of double-strand break

Known as: DNA damage foci, site of DSB, DNA damage focus 
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Poly (ADP-ribose) polymerases (PARPs) play an important role in various cellular processes, such as replication, recombination… Expand
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Review
2010
Review
2010
DNA non-homologous end-joining (NHEJ) and homologous recombination (HR) represent the major DNA double strand break (DSB… Expand
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Highly Cited
2010
Highly Cited
2010
DNA double-strand breaks (DSBs) trigger ATM (ataxia telangiectasia mutated) signalling and elicit genomic rearrangements and… Expand
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Highly Cited
2009
Highly Cited
2009
DNA double-strand breaks (DSBs) are highly cytotoxic lesions that are generated by ionizing radiation and various DNA-damaging… Expand
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Highly Cited
2005
Highly Cited
2005
Activating transcription factor 2 (ATF2) is regulated by JNK/p38 in response to stress. Here, we demonstrate that the protein… Expand
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Highly Cited
2004
Highly Cited
2004
Humans and animals undergo ageing, and although their primary cells undergo cellular senescence in culture, the relationship… Expand
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Highly Cited
2004
Highly Cited
2004
Microcephalin (MCPH1) is the first gene identified among at least six loci that contribute to the autosomal recessive disease… Expand
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Highly Cited
2003
Highly Cited
2003
Histone H2AX is rapidly phosphorylated in the chromatin micro-environment surrounding a DNA double-strand break (DSB). Although… Expand
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Highly Cited
2001
Highly Cited
2001
Fanconi anemia (FA) is a human autosomal recessive cancer susceptibility disorder characterized by cellular sensitivity to… Expand
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Highly Cited
1998
Highly Cited
1998
Nijmegen breakage syndrome (NBS) is an autosomal recessive disorder characterized by increased cancer incidence, cell cycle… Expand
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