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sirtinol

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2002-2018
010203020022018

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2 relations

Broader (2)

BenzamidesNaphthols

Related mentions per year

Related mentions per year

1940-2018
19401960198020002020
sirtinol
Naphthols
Benzamides

Papers overview

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2012
2012
Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells.
BACKGROUND Elevated levels of survivin and histone deacetylases (HDACs) are often found over-expressed in human cancers… (More)
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2012
2012
Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells.
Sirtuins (SIRTs), NAD+-dependent class III histone deacetylases (HDACs), play an important role in the regulation of cell… (More)
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2012
2012
High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells.
Adult T-cell leukemia-lymphoma (ATL) is an aggressive peripheral T-cell neoplasm that develops after long-term infection with… (More)
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2011
2011
Sirtinol Treatment Reduces Inflammation in Human Dermal Microvascular Endothelial Cells
Histone deacetylases (HDAC) are key enzymes in the epigenetic control of gene expression. Recently, inhibitors of class I and… (More)
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Highly Cited
2009
Highly Cited
2009
Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway.
Resveratrol is a natural polyphenol found in grapes and wine and has been associated with protective effects against… (More)
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Highly Cited
2007
Highly Cited
2007
Sirt1 modulates premature senescence-like phenotype in human endothelial cells.
Yeast Sir2 plays critical roles in gene silencing, stress resistance and longevity. Mammalian Sirt1 NAD(+)-dependent protein… (More)
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Highly Cited
2006
Highly Cited
2006
Resveratrol mimics ischemic preconditioning in the brain.
Recent studies in a variety of species including mammals showed that resveratrol (trans-3, 5, 4''-trihydroxystibene) treatment… (More)
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2005
2005
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.
In a search for potent inhibitors of class III histone/protein deacetylases (sirtuins), a series of sirtinol analogues have been… (More)
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2005
2005
Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis.
The synthetic molecule sirtinol was shown previously to activate the auxin signal transduction pathway. Here we present a… (More)
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Highly Cited
2004
Highly Cited
2004
Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes.
Yeast silent information regulator 2 (Sir2), a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) and… (More)
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