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sirtinol

 
National Institutes of Health

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BenzamidesNaphthols

Papers overview

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2012
2012
Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells.
BACKGROUND Elevated levels of survivin and histone deacetylases (HDACs) are often found over-expressed in human cancers… Expand
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Highly Cited
2012
Highly Cited
2012
Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells.
Sirtuins (SIRTs), NAD+-dependent class III histone deacetylases (HDACs), play an important role in the regulation of cell… Expand
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Highly Cited
2010
Highly Cited
2010
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.
SIRT proteins play an important role in the survival and drug resistance of tumor cells, especially during chemotherapy. In this… Expand
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Highly Cited
2009
Highly Cited
2009
Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway
Resveratrol is a natural polyphenol found in grapes and wine and has been associated with protective effects against… Expand
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Highly Cited
2009
Highly Cited
2009
Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines.
Dysregulation of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) has been implicated in the… Expand
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Highly Cited
2007
Highly Cited
2007
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging.
The silent information regulator 2 (Sir2) family of proteins (sirtuins or SIRTs), which belong to class III histone/protein… Expand
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Highly Cited
2007
Highly Cited
2007
Sirt1 modulates premature senescence-like phenotype in human endothelial cells.
Yeast Sir2 plays critical roles in gene silencing, stress resistance and longevity. Mammalian Sirt1 NAD(+)-dependent protein… Expand
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Highly Cited
2006
Highly Cited
2006
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras–MAPK signaling in human cancer cells
The induction of senescence-like growth arrest has emerged as a putative contributor to the anticancer effects of… Expand
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Highly Cited
2005
Highly Cited
2005
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.
In a search for potent inhibitors of class III histone/protein deacetylases (sirtuins), a series of sirtinol analogues have been… Expand
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Highly Cited
2004
Highly Cited
2004
Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes.
Yeast silent information regulator 2 (Sir2), a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) and… Expand
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