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signal peptide processing

Known as: leader peptide processing 
The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. [GOC:mah, ISBN:0815316194]
National Institutes of Health

Papers overview

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2019
2019
Zn-dependent bifunctional proteases are responsible for leader peptide processing of class III lanthipeptides
Significance Lanthipeptides represent one of the largest classes of peptide natural products with a ribosomal origin, and their… 
Highly Cited
2016
Highly Cited
2016
A CRISPR screen defines a signal peptide processing pathway required by flaviviruses
Flaviviruses infect hundreds of millions of people annually, and no antiviral therapy is available. We performed a genome-wide… 
Review
2014
Review
2014
Secretion of bacterial lipoproteins: through the cytoplasmic membrane, the periplasm and beyond.
  • W. Zückert
  • Biochimica et Biophysica Acta
  • 2014
  • Corpus ID: 22918938
2012
2012
Multiple Roles of the Cox20 Chaperone in Assembly of Saccharomyces cerevisiae Cytochrome c Oxidase
The Cox2 subunit of Saccharomyces cerevisiae cytochrome c oxidase is synthesized in the mitochondrial matrix as a precursor whose… 
2004
2004
Prototype Foamy Virus Envelope Glycoprotein Leader Peptide Processing Is Mediated by a Furin-Like Cellular Protease, but Cleavage Is Not Essential for Viral Infectivity
ABSTRACT Analogous to cellular glycoproteins, viral envelope proteins contain N-terminal signal sequences responsible for… 
Review
2003
Review
2003
Control of lipid metabolism by regulated intramembrane proteolysis of sterol regulatory element binding proteins (SREBPs).
  • R. B. Rawson
  • Biochemical Society Symposium
  • 2003
  • Corpus ID: 9022165
In mammalian cells, the supply of lipids is co-ordinated with demand through the transcriptional control of genes encoding… 
Highly Cited
2003
Highly Cited
2003
The YSIRK-G/S Motif of Staphylococcal Protein A and Its Role in Efficiency of Signal Peptide Processing
ABSTRACT Many surface proteins of pathogenic gram-positive bacteria are linked to the cell wall envelope by a mechanism requiring… 
Highly Cited
1996
Highly Cited
1996
Novel insights into the genetics, biochemistry, and immunocytochemistry of the 30-kilodalton major extracellular protein of Mycobacterium tuberculosis
The 30/32-kDa complex of major secretory proteins are among the most important and intensively studied proteins of Mycobacterium… 
Highly Cited
1994
Highly Cited
1994
Evidence for importance of the Staphylococcus hyicus lipase pro-peptide in lipase secretion, stability and activity.
To investigate the function of the pro-peptide (PP) region of the Staphylococcus hyicus exolipase, restriction sites were created… 
Highly Cited
1988
Highly Cited
1988
SEC11 is required for signal peptide processing and yeast cell growth
Among the collection of temperature-sensitive secretion mutants of Saccharomyces cerevisiae, sec11 mutant cells are uniquely… 
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