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signal peptide processing

Known as: leader peptide processing 
The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. [GOC:mah, ISBN:0815316194]
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
A CRISPR screen defines a signal peptide processing pathway required by flaviviruses
Flaviviruses infect hundreds of millions of people annually, and no antiviral therapy is available. We performed a genome-wide… Expand
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Review
2014
Review
2014
Secretion of bacterial lipoproteins: through the cytoplasmic membrane, the periplasm and beyond.
Bacterial lipoproteins are peripherally anchored membrane proteins that play a variety of roles in bacterial physiology and… Expand
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2012
2012
Structural Analysis of Hepatitis C Virus Core-E1 Signal Peptide and Requirements for Cleavage of the Genotype 3a Signal Sequence by Signal Peptide Peptidase
ABSTRACT The maturation of the hepatitis C virus (HCV) core protein requires proteolytic processing by two host proteases: signal… Expand
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2008
2008
Functional analysis of an ADAMTS10 signal peptide mutation in Weill-Marchesani syndrome demonstrates a long-range effect on secretion of the full-length enzyme.
We report the identification and functional analysis of the first missense ADAMTS10 mutation (c.73G>A; p.Ala25Thr) causing… Expand
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2004
2004
Prototype foamy virus envelope glycoprotein leader peptide processing is mediated by a furin-like cellular protease, but cleavage is not essential for viral infectivity.
Analogous to cellular glycoproteins, viral envelope proteins contain N-terminal signal sequences responsible for targeting them… Expand
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Highly Cited
2003
Highly Cited
2003
The YSIRK-G/S motif of staphylococcal protein A and its role in efficiency of signal peptide processing.
Many surface proteins of pathogenic gram-positive bacteria are linked to the cell wall envelope by a mechanism requiring a C… Expand
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Highly Cited
1996
Highly Cited
1996
Novel insights into the genetics, biochemistry, and immunocytochemistry of the 30-kilodalton major extracellular protein of Mycobacterium tuberculosis.
The 30/32-kDa complex of major secretory proteins are among the most important and intensively studied proteins of Mycobacterium… Expand
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1994
1994
Evidence for importance of the Staphylococcus hyicus lipase pro-peptide in lipase secretion, stability and activity.
To investigate the function of the pro-peptide (PP) region of the Staphylococcus hyicus exolipase, restriction sites were created… Expand
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Highly Cited
1988
Highly Cited
1988
SEC11 is required for signal peptide processing and yeast cell growth
Among the collection of temperature-sensitive secretion mutants of Saccharomyces cerevisiae, sec11 mutant cells are uniquely… Expand
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1988
1988
Correct glycosylation, Golgi-processing, and targeting to protein bodies of the vacuolar protein phytohemagglutinin in transgenic tobacco
We used a heterologous system (transgenic Nicotiana tabacum L.) to investigate the processing, assembly and targeting of… Expand
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