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The general objective of this thesis is to demonstrate the synthetic utility of the domino concept in the complex setting of… Expand To identify antibiotics targeting to respiratory enzymes, we carried out matrix screening of a structurally varied natural… Expand The sensitivity of Candida albicans to antifungal drugs when cultured under aerobic and anaerobic conditions was measured… Expand The synthesis of biologically active natural and synthetic compounds is without doubt a topical field of activity. A forum for… Expand (-)-Siccanin (1), a natural product possessing significant antifungal properties, was synthesized enantioselectively via a… Expand The therapeutic efficacy of a topical antifungal ointment containing 2% tolnaftate was studied in a guinea pig model of tinea… Expand Acute toxicity of nanaomycin A was tested in mice and rats. It was found that the antibiotic was well absorbed topically so that… Expand Siccanin at 3 μg/ml completely inhibited the growth of Trichophyton mentagrophytes. The primary site of action of siccanin on T… Expand