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Abstract 1. Several sodium-glucose cotransporter-2 (SGLT-2) inhibitors are in clinical use for the management of type 2 diabetes… Expand The incidence of type 2 diabetes mellitus is increasing worldwide. The pharmacotherapy for type 2 diabetes until the last decade… Expand Despite availability of a number of oral antidiabetics, a sizeable population of diabetics remains uncontrolled. Thus there is… Expand The incidence of type 2 diabetes mellitus is increasing worldwide. The existing therapeutic classes of antidiabetic drugs are not… Expand C-Aryl 5a-carba-β-d-glucopyranose derivatives were synthesized and evaluated for inhibition activity against hSGLT1 and hSGLT2… Expand The physiological and pathological handling of glucose via sodium-glucose cotransporter-2 (SGLT2) in the kidneys has been… Expand 5a-Carba-β-D-glucopyranose derivatives were synthesized and identified as novel SGLT2-selective inhibitors. These inhibitors… Expand The kidneys play a major role in the regulation of glucose in humans, reabsorbing 99% of the plasma glucose that filters through… Expand OBJECTIVE
To review the renal handling of glucose and the role of inhibition of a sodium-glucose transporter (SGLT2) in the… Expand