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separase-securin complex

Known as: Cut1-2 complex, Cut1-2 complex location, separase-securin complex location 
A protein complex that includes separase and securin as components and that inhibits chromosome separation at mitosis. [GOC:dos, GOC:vw, PMID:8978688… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
The cysteine protease separase opens the cohesin ring by cleaving its kleisin subunit and is a pivotal cell cycle factor for the… Expand
2017
2017
Separases are crucial cell cycle proteases that control the metaphase-to-anaphase transition by cleaving chromosomal cohesin… Expand
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2016
2016
The protease separase plays a key role in sister chromatid disjunction and centriole disengagement. To maintain genomic stability… Expand
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2014
2014
PTTG1 protein, the human securin, has a central role in sister chromatid separation during mitosis, and its altered expression… Expand
Highly Cited
2014
Highly Cited
2014
Background:Cdc20 is an essential component of cell division and responsible for anaphase initiation regulated by securin… Expand
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Review
2013
Review
2013
Cell cycle regulators cdc27 and securin participate in control of the mitotic checkpoint and survey the mitotic spindle to… Expand
2009
2009
Background:Securin is a recently recognised oncogene with multiple known functions in initiation, progression and cell cycle… Expand
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2007
2007
THE STICKING POINT: HUMAN RIGHTS AND CIVIL-MILITARY RELATIONS IN LATIN AMERICA LEBRUARY 2007 REBECCA K. ROOT. B.A.. ECKERD… Expand
Highly Cited
2005
Highly Cited
2005
Accurate partition of duplicated genetic material to the daughter cells during mitosis relies on the maintenance of the physical… Expand
2002
2002
Background: The separase‐securin complex is required for anaphase. Separase activated by securin destruction cleaves the cohesin… Expand