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separase-securin complex

Known as: Cut1-2 complex, Cut1-2 complex location, separase-securin complex location 
A protein complex that includes separase and securin as components and that inhibits chromosome separation at mitosis. [GOC:dos, GOC:vw, PMID:8978688… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Structural biology of the separase-securin complex with crucial roles in chromosome segregation.
The cysteine protease separase opens the cohesin ring by cleaving its kleisin subunit and is a pivotal cell cycle factor for the… Expand
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2017
2017
Separase–securin complex: a cunning way to control chromosome segregation
Separases are crucial cell cycle proteases that control the metaphase-to-anaphase transition by cleaving chromosomal cohesin… Expand
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2016
2016
A closed conformation of the Caenorhabditis elegans separase–securin complex
The protease separase plays a key role in sister chromatid disjunction and centriole disengagement. To maintain genomic stability… Expand
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2014
2014
Prostate Cancer Cell Response to Paclitaxel Is Affected by Abnormally Expressed Securin PTTG1
PTTG1 protein, the human securin, has a central role in sister chromatid separation during mitosis, and its altered expression… Expand
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Highly Cited
2014
Highly Cited
2014
Cdc20 and securin overexpression predict short-term breast cancer survival
Background:Cdc20 is an essential component of cell division and responsible for anaphase initiation regulated by securin… Expand
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Review
2013
Review
2013
Low cdc27 and high securin expression predict short survival for breast cancer patients
Cell cycle regulators cdc27 and securin participate in control of the mitotic checkpoint and survey the mitotic spindle to… Expand
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2009
2009
Securin promotes the identification of favourable outcome in invasive breast cancer
Background:Securin is a recently recognised oncogene with multiple known functions in initiation, progression and cell cycle… Expand
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2007
2007
The sticking point: Human rights and civil -military relations in Latin America
THE STICKING POINT: HUMAN RIGHTS AND CIVIL-MILITARY RELATIONS IN LATIN AMERICA LEBRUARY 2007 REBECCA K. ROOT. B.A.. ECKERD… Expand
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Highly Cited
2005
Highly Cited
2005
Bub1 Multitasking in Mitosis
Accurate partition of duplicated genetic material to the daughter cells during mitosis relies on the maintenance of the physical… Expand
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2002
2002
Cut1/separase C‐terminus affects spindle pole body positioning in interphase of fission yeast: pointed nuclear formation
Background: The separase‐securin complex is required for anaphase. Separase activated by securin destruction cleaves the cohesin… Expand
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