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separase-securin complex
Known as:
Cut1-2 complex
, Cut1-2 complex location
, separase-securin complex location
A protein complex that includes separase and securin as components and that inhibits chromosome separation at mitosis. [GOC:dos, GOC:vw, PMID:8978688…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Structural biology of the separase-securin complex with crucial roles in chromosome segregation.
Shukun Luo
,
L. Tong
Current Opinion in Structural Biology
2018
Corpus ID: 3335961
2017
2017
Separase–securin complex: a cunning way to control chromosome segregation
M. Singleton
,
F. Uhlmann
Nature Structural &Molecular Biology
2017
Corpus ID: 20424753
Separases are crucial cell cycle proteases that control the metaphase-to-anaphase transition by cleaving chromosomal cohesin…
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2016
2016
A closed conformation of the Caenorhabditis elegans separase–securin complex
Gudrun Bachmann
,
M. Richards
,
A. Winter
,
F. Beuron
,
E. Morris
,
R. Bayliss
Open Biology
2016
Corpus ID: 1023735
The protease separase plays a key role in sister chromatid disjunction and centriole disengagement. To maintain genomic stability…
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2014
2014
Prostate Cancer Cell Response to Paclitaxel Is Affected by Abnormally Expressed Securin PTTG1
C. Castilla
,
M. L. Flores
,
+5 authors
C. Sáez
Molecular Cancer Therapeutics
2014
Corpus ID: 25266319
PTTG1 protein, the human securin, has a central role in sister chromatid separation during mitosis, and its altered expression…
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Highly Cited
2014
Highly Cited
2014
Cdc20 and securin overexpression predict short-term breast cancer survival
H. Karra
,
H. Repo
,
+6 authors
P. Kronqvist
British Journal of Cancer
2014
Corpus ID: 11017131
Background:Cdc20 is an essential component of cell division and responsible for anaphase initiation regulated by securin…
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Review
2013
Review
2013
Low cdc27 and high securin expression predict short survival for breast cancer patients
K. Talvinen
,
H. Karra
,
+6 authors
P. Kronqvist
Acta Pathologica, Microbiologica et Immunologica…
2013
Corpus ID: 40779988
Cell cycle regulators cdc27 and securin participate in control of the mitotic checkpoint and survey the mitotic spindle to…
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2009
2009
Securin promotes the identification of favourable outcome in invasive breast cancer
K. Talvinen
,
H. Karra
,
+5 authors
P. Kronqvist
British Journal of Cancer
2009
Corpus ID: 10063811
Background:Securin is a recently recognised oncogene with multiple known functions in initiation, progression and cell cycle…
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2007
2007
The sticking point: Human rights and civil -military relations in Latin America
R. Root
2007
Corpus ID: 150772027
THE STICKING POINT: HUMAN RIGHTS AND CIVIL-MILITARY RELATIONS IN LATIN AMERICA LEBRUARY 2007 REBECCA K. ROOT. B.A.. ECKERD…
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Highly Cited
2005
Highly Cited
2005
Bub1 Multitasking in Mitosis
Hongtao Yu
,
Zhanyun Tang
Cell Cycle
2005
Corpus ID: 30495136
Accurate partition of duplicated genetic material to the daughter cells during mitosis relies on the maintenance of the physical…
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2002
2002
Cut1/separase C‐terminus affects spindle pole body positioning in interphase of fission yeast: pointed nuclear formation
Takahiro Nakamura
,
K. Nagao
,
Y. Nakaseko
,
M. Yanagida
Genes to Cells
2002
Corpus ID: 40575399
Background: The separase‐securin complex is required for anaphase. Separase activated by securin destruction cleaves the cohesin…
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