selegiline hydrochloride

Known as: Hydrochloride, Selegiline, Selegiline Hydrochloride, (R)-Isomer [Chemical/Ingredient], L-deprenyl Hydrochloride 
The hydrochloride salt form of selegiline, a levorotatory acetylenic derivative of phenethylamine with antiparkinsonian effect. As a selective… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1978-2018
0102019782018

Papers overview

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Highly Cited
2011
Highly Cited
2011
The accumulation of β-amyloid in the brain is an early event in Alzheimer's disease. This study presents the first patient with… (More)
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2007
2007
OBJECTIVE To use deuterium-substituted [11C](L)-deprenyl PET to depict astrocytosis in vivo in patients with amyotrophic lateral… (More)
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2006
2006
Human immunodeficiency virus (HIV) infection continues to rise in drug-abusing populations and causes a dementing illness in a… (More)
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2003
2003
BACKGROUND Since dopaminergic mechanisms appear to be involved in nicotine dependence, we studied the safety and efficacy of the… (More)
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Highly Cited
1995
Highly Cited
1995
3,4-Methylenedioxymethamphetamine (MDMA)-induced serotonergic neurotoxicity was assessed in the striatum, hippocampus and frontal… (More)
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Highly Cited
1994
Highly Cited
1994
Chronic (14 day) but not acute (1 day) treatment of mice with clinically active antidepressants produces a significant… (More)
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Highly Cited
1994
Highly Cited
1994
L-Deprenyl (Selegeline) is an enzyme-activated irreversible inhibitor of monoamine oxidase B (MAO B; EC 1.4.3.4). It is used to… (More)
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Highly Cited
1992
Highly Cited
1992
Monoamine oxidases A and B (MAO-A and MAO-B) oxidatively deaminate neurotransmitter and xenobiotic amines. Since the cellular… (More)
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Highly Cited
1987
Highly Cited
1987
The regional distributions of monoamine oxidase (MAO) types A and B have been identified in human brain in vivo with… (More)
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1987
1987
The distribution of carbon-11-labeled L-deprenyl, an irreversible inhibitor of monoamine oxidase type B (MAO-B), was determined… (More)
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