saxagliptin

Known as: (1S,3S,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl) acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile hydrate, 3-hydroxyadamantylglycine-4,5-methanoprolinenitrile hydrate 
A potent, selective and competitive, cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic… (More)

Topic mentions per year

Topic mentions per year

2005-2017
05020052017

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND Diabetes mellitus and heart failure frequently coexist. However, few diabetes mellitus trials have prospectively… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND The cardiovascular safety and efficacy of many current antihyperglycemic agents, including saxagliptin, a dipeptidyl… (More)
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2011
2011
AIM To evaluate the efficacy and safety of saxagliptin vs. placebo in patients with type 2 diabetes mellitus (T2DM) and renal… (More)
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Highly Cited
2009
Highly Cited
2009
OBJECTIVE To evaluate the efficacy and safety of once-daily saxagliptin monotherapy in treatment-naïve patients with type 2… (More)
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Highly Cited
2009
Highly Cited
2009
OBJECTIVE This 24-week trial assessed the efficacy and safety of saxagliptin as add-on therapy in patients with type 2 diabetes… (More)
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Highly Cited
2009
Highly Cited
2009
CONTEXT Due to the natural progression of type 2 diabetes (T2D), most patients require combination therapy to maintain glycemic… (More)
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Highly Cited
2009
Highly Cited
2009
AIMS Assess the efficacy and safety of saxagliptin added to a submaximal sulphonylurea dose vs. uptitration of sulphonylurea… (More)
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Highly Cited
2009
Highly Cited
2009
AIM The study aim was to evaluate the efficacy and safety of initial combination therapy with saxagliptin + metformin vs… (More)
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Highly Cited
2008
Highly Cited
2008
AIM Enhancing the physiologic actions of the endogenous incretin hormones, glucagon-like peptide-1 and glucose-dependent… (More)
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Highly Cited
2005
Highly Cited
2005
Efforts to further elucidate structure-activity relationships (SAR) within our previously disclosed series of beta-quaternary… (More)
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