rosuvastatin lactone
National Institutes of Health
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A microfluidic liver biochip was coupled with a mass spectrometer to detect in real time the drug metabolism of hepatocytes. The…
Rosuvastatin disposition is modulated by the expression and activity of several membrane transporters including BCRP (ABCG2). The…
Cardiovascular disorders are the leading cause of death in the United States. Members of 3-hydroxy-3-methylglutaryl-coenzyme A…
The relaxant effect of the lactone of rosuvastatin was evaluated on aortic rings from male Wistar rats (250-300 g) with and…
The first entry to statins via lactonized side chain is reported, exemplified by the synthesis of rosuvastatin. The key step is…